Clinical characteristics and outcomes of children with prolonged mechanical ventilation in PICUs in mainland China: A national survey
作者全名:"Zhang, Zhengzheng; Tao, Jinhao; Cai, Xiaodi; Huang, Li; Liu, Chengjun; Ren, Hong; Qu, Dong; Gao, Hengmiao; Cheng, Yibing; Zhang, Furong; Yang, Zihao; Xu, Wei; Miao, Hongjun; Liu, Pan; Liu, Yuxin; Lu, Guoping; Chen, Weiming"
作者地址:"[Zhang, Zhengzheng; Tao, Jinhao; Cai, Xiaodi; Liu, Pan; Liu, Yuxin; Lu, Guoping; Chen, Weiming] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Pediat Intens Care Unit, Shanghai, Peoples R China; [Huang, Li] Guangzhou Women & Childrens Med Ctr, Natl Childrens Med Ctr South Cent Reg, Dept Pediat, Intens Care Unit, Guangzhou, Peoples R China; [Liu, Chengjun] Chongqing Med Univ, Childrens Hosp, Intens Care Unit, Western Pediat Dev Union,Dept Pediat, Chongqing, Peoples R China; [Ren, Hong] Shanghai Jiao Tong Univ, Sch Med, Natl Childrens Med Ctr, Shanghai Childrens Med Ctr,Dept Pediat,Intens Care, Shanghai, Peoples R China; [Qu, Dong] Childrens Hosp, Capital Inst Pediat, Dept Pediat, Intens Care Unit, Beijing, Peoples R China; [Gao, Hengmiao] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Pediat,Intens Care Unit, Beijing, Peoples R China; [Cheng, Yibing] Zhengzhou Univ, Childrens Hosp, Dept Pediat, Intens Care Unit, Zhengzhou, Peoples R China; [Zhang, Furong] Huazhong Univ Sci & Technol, Wuhan Children's Hosp, Tongji Med Coll, Dept Pediat,Intens Care Unit, Wuhan, Hubei, Peoples R China; [Yang, Zihao] Childrens Hosp Zhejiang Univ Sch Med, Natl Clin Res Ctr Child Hlth, Dept Pediat, Intens Care Unit, Hangzhou, Zhejiang, Peoples R China; [Xu, Wei] China Med Univ, Shengjing Hosp, Natl Childrens Northeast Reg Med Ctr, Dept Pediat,Intens Care Unit, Shenyang, Peoples R China; [Miao, Hongjun] Nanjing Med Univ, Childrens Hosp, Dept Emergency Crit Med, Nanjing, Jiangsu, Peoples R China"
通信作者:"Chen, WM (通讯作者),Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Pediat Intens Care Unit, Shanghai, Peoples R China."
来源:PEDIATRIC PULMONOLOGY
ESI学科分类:CLINICAL MEDICINE
WOS号:WOS:000929063000001
JCR分区:Q1
影响因子:2.7
年份:2023
卷号:58
期号:5
开始页:1401
结束页:1410
文献类型:Article
关键词:children; chronic respiratory failure; epidemiology; pediatric intensive care unit; prolonged mechanical ventilation
摘要:"ObjectiveThe number of children on prolonged mechanical ventilation (PMV) in pediatric intensive care units (PICU) has increased markedly, but little is known about the situation in mainland China. We carried out a multicenter retrospective investigation to describe the clinical characteristics and prognosis of Chinese children receiving long-term ventilation in the PICU. MethodsA retrospective study was performed in 11 PICUs. All participating patients with prolonged mechanical ventilation in the study were retrospectively identified and included from cases admitted to PICUs between January 1, 2017 and December 31, 2019. ResultsA total of 346 children diagnosed with prolonged mechanical ventilation were included in the study. Overall, 240 survived and were discharged from PICU, 55 died in hospital, and 51 withdrew from mechanical ventilation support with 41 died after discharge. Lower airway diseases were the most common underlying causes (41.6%), followed by central nervous system diseases (29.5%), and neuromuscular diseases (13.3%). Most children (327, 94.5%) received invasive mechanical ventilation (IMV) and only 19 (5.5%) children received noninvasive ventilation (NIV). The median time of tracheostomy after ventilation was 21 days (15-35). Children with tracheostomy had lower mortality with longer PICU stay compared with patients without tracheostomy. Children who underwent tracheostomy were more likely to have central nervous system diseases and neuromuscular diseases. ConclusionThis study showed a steady increase in the number of children receiving prolonged mechanical ventilation during the study period in Chinese PICUs with distinct clinical characteristics and outcomes. A better community-based care for PMV children is needed in mainland China."
基金机构:National Key Research and Development Program of China; Shanghai Shenkang Hospital Development Center
基金资助正文:National Key Research and Development Program of China; Shanghai Shenkang Hospital Development Center