Functionalized Cortical Bone-Inspired Composites Adapt to the Mechanical and Biological Properties of the Edentulous Area to Resist Fretting Wear

作者全名："Wang, ZhongYi; Xiang, QianRong; Tan, Xin; Zhang, YaDong; Zhu, HaoQi; Pu, Jian; Sun, JiKui; Sun, ManLin; Wang, YingKai; Wei, Qiang; Yu, HaiYang"

作者地址："[Wang, ZhongYi; Xiang, QianRong; Tan, Xin; Sun, JiKui; Sun, ManLin; Wang, YingKai; Yu, HaiYang] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China; [Tan, Xin] Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 400016, Peoples R China; [Zhang, YaDong] Zhejiang PEKK X Adv Mat Technol Co Ltd, Res & Dev Dept, Shaoxing 312000, Zhejiang, Peoples R China; [Zhu, HaoQi] City Univ Hong Kong, Dept Phys, Kowloon, Hong Kong 999077, Peoples R China; [Pu, Jian] Southwest Jiaotong Univ, Sch Mech Engn, Chengdu 610031, Sichuan, Peoples R China; [Wei, Qiang] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat & Engn, Chengdu 610065, Sichuan, Peoples R China"

通信作者："Yu, HY (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China.; Wei, Q (通讯作者)，Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat & Engn, Chengdu 610065, Sichuan, Peoples R China."

来源：ADVANCED SCIENCE

ESI学科分类：PHYSICS

WOS号：WOS:000929504700001

JCR分区：Q1

影响因子：14.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：biological-mechanical adaptivity; dentition defects; fretting wear; implant-bone interface; zirconia

摘要："Dental implants with long-term success of osseointegration have always been the goal, however, difficulties exist. The accumulation of fretting damage at the implant-bone interface often gets overlooked. Commonly used titanium is approximately 7-fold harder and stiffer than cortical bone. Stress shielding caused by the mismatching of the elastic modulus aggravates fretting at the interface, which is accompanied by the risk of the formation of proinflammatory metal debris and implant loosening. Thus, the authors explore functionalized cortical bone-inspired composites (FCBIC) with a hierarchical structure at multiple scales, that exhibit good mechanical and biological adaptivity with cortical bone. The design is inspired by nature, combining brittle minerals with organic molecules to maintain machinability, which helps to acquire excellent energy-dissipating capability. It therefore has the comparable hardness and elastic modulus, strength, and elastic-plastic deformation to cortical bone. Meanwhile, this cortical bone analogy exhibits excellent osteoinduction and osseointegration abilities. These two properties also facilitate each other to resist fretting wear, and therefore improve the success rate of implantation. Based on these results, the biological-mechanical co-operation coefficient is proposed to describe the coupling between these two factors for designing the optimized dental implants."

基金机构："National Natural Science Foundation of China [82271020, 82071145]; Research Fund of Interdisciplinary Innovation Project from West China Hospital of Stomatology, Sichuan University [RD-03-202009]"

基金资助正文："Z.W., Q.X., and X.T. contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (Nos. 82271020 and 82071145) and the Research F<STRONG>und of Interdisciplinary Innovation Project from West China Hospital of Stomatology, Sichuan University (RD-03-202009)</STRONG>. The authors thank Dr. Qiang Wei (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University) for guidance in using environmental scanning electron microscope (ESEM, No. 2020C017), white light interferometer 3D surface profilometer (No. 2020ACA0), automatic polishing machine (No. 20207435), and friction and wear tester (No. 20209FBC). The authors also thank Mr. Xufang Zhou in Changzhou Easuta Dental Medical Instrument Co. Ltd., who offered tools for animal experiments. The experiments with human subjects was approved by the Research Ethics Committee of West China Hospital of Stomatology (WCHSIRB-CT-2022-084) and were carried out with the full, informed consent of the subjects. The animal experiments were performed according to the protocols approved by the Research Ethics Committee of West China Hospital of Stomatology (WCHSIRB-CT-2022-084)."