Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1 alpha/VEGF/eNOS/NO signal pathway

作者全名："Long, Yu; Liu, Songyu; Wan, Jinyan; Zhang, Yulu; Li, Dan; Yu, Shuang; Shi, Ai; Li, Nan; He, Fei"

作者地址："[Long, Yu; Liu, Songyu; Zhang, Yulu; Li, Dan; Shi, Ai; Li, Nan] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166, Liutai Ave, Chengdu 611137, Peoples R China; [He, Fei] Chongqing Med Univ, Yongchuan Hosp, 439, Xuanhua Rd, Chongqing 402160, Peoples R China"

通信作者："Li, N (通讯作者)，Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166, Liutai Ave, Chengdu 611137, Peoples R China.; He, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, 439, Xuanhua Rd, Chongqing 402160, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000931586000001

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：160

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Cerebral ischemia-reperfusion injury; Borneol-baicalin liposome; Blood -brain barrier; Pharmacodynamics; Pharmacokinetics

摘要："Baicalin (BA) is widely used in the treatment of cerebral ischemia-reperfusion injury (CIRI). The key to treating encephalopathy is to increase the amounts of drugs entering the brain. Borneol-baicalin liposome (BO-BA-LP) was prepared in previous research based on the characteristics of borneol (BO) in promoting drug brain entry. In this study, the effect of BO-BA-LP on improving blood-brain barrier (BBB) integrity was researched. Results showed BO-BA-LP may increase ability of BA to penetrate the cell membrane in vitro. Pharmacokinetic results showed the BO-BA-LP could increase concentrations of BA in plasma and brain tissues of normal and CIRI mice. Pharmacological results revealed BO-BA-LP could improve the neurological function, brain edema, and histopathology of CIRI mice. Besides, BO-BA-LP could protect BBB by regulating hypoxia inducible factor-1 alpha (HIF1 alpha)/vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway. The research showed that BO in BO-BA-LP could increase the absorption of BA by increasing BBB permeability, leading to a better therapeutic effect of BO-BA-LP on CIRI mice."

基金机构："Chongqing Kewei Joint Medical Research Project [2022MSXM177]; Science & Technology Department of Sichuan Province [2022NSFSC1406]; National Talent Project of Traditional Chinese Medicine Characteristic Technology Inheritance [T20194828003]; Xinglin Scholar Discipline Promotion Talent Program of Chengdu University of Traditional Chinese Medicine [QNXZ2018018, XGZX2010]; Chengdu University of Traditional Chinese Medicine Youth Foundation Advanced Talents Project [QJJJ2022014]; Chengdu University of Traditional Chinese Medicine Rural Revitalization Project [XCZX2022007]"

基金资助正文："This work was supported by Chongqing Kewei Joint Medical Research Project [Grant Number: 2022MSXM177], Science & Technology Department of Sichuan Province [Grant Number: 2022NSFSC1406], National Talent Project of Traditional Chinese Medicine Characteristic Technology Inheritance [Grant Number: T20194828003], Xinglin Scholar Discipline Promotion Talent Program of Chengdu University of Traditional Chinese Medicine [Grant Numbers: QNXZ2018018, XGZX2010], Chengdu University of Traditional Chinese Medicine Youth Foundation Advanced Talents Project [Grant Number: QJJJ2022014] and Chengdu University of Traditional Chinese Medicine Rural Revitalization Project [Grant Number: XCZX2022007] ."