"Crystal structure of monkeypox H1 phosphatase, an antiviral drug target"

作者全名："Cui, Wen; Huang, Haojun; Duan, Yinkai; Luo, Zhi; Wang, Haofeng; Zhang, Tenan; Nguyen, Henry C.; Shen, Wei; Su, Dan; Li, Xi; Ji, Xiaoyun; Yang, Haitao; Wang, Wei"

作者地址："[Cui, Wen; Huang, Haojun; Luo, Zhi; Zhang, Tenan; Su, Dan; Li, Xi; Ji, Xiaoyun; Wang, Wei] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Duan, Yinkai; Wang, Haofeng; Nguyen, Henry C.; Shen, Wei; Yang, Haitao] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Su, Dan] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610064, Peoples R China; [Ji, Xiaoyun] Nanjing Univ, Sch Life Sci, Dept Biotechnol & Pharmaceut Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Yang, Haitao] Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China; [Yang, Haitao] Tianjin Int Joint Acad Biotechnol & Med, Tianjin 300450, Peoples R China"

通信作者："Ji, XY; Wang, W (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.; Yang, HT (通讯作者)，ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.; Ji, XY (通讯作者)，Nanjing Univ, Sch Life Sci, Dept Biotechnol & Pharmaceut Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China.; Yang, HT (通讯作者)，Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China.; Yang, HT (通讯作者)，Tianjin Int Joint Acad Biotechnol & Med, Tianjin 300450, Peoples R China."

来源：PROTEIN & CELL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000932377400001

JCR分区：Q1

影响因子：13.6

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Letter; Early Access

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基金机构："National Natural Science Foundation of China [81902063, 81871639, 92169109]; Ministry of Science and Technology of the People's Republic of China [2018YFA0507100, 2020YFA0707500]; Chongqing Science and Technology Commission [cstc2019jcyj-msxmX0135]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000442]; CQMU Chongqing Medical University [W0073]; Lingang Laboratory [LG202101-01-07]; Science and Technology Commission of Shanghai Municipality [YDZX20213100001556, 20XD1422900]; Natural Science Foundation of Tianjin [18JCJQJC48000]; Shanghai Municipal Development & Reform Commission Major Project [ZD2021CY001]; Shanghai Frontiers Science Center; Precision Medicine, ShanghaiTech University"

基金资助正文："We are grateful to the staff at the BL18U1 at Shanghai Synchrotron Radiation Facility (SSRF, China), where data were collected. This<EM><STRONG> </STRONG></EM>work was supported by grants from the National Natural Science Foundation of China (Nos. 81902063, 81871639, and 92169109) and Ministry of Science and Technology of the People's Republic of China (Nos. 2018YFA0507100 and 2020YFA0707500). This work was also supported by the Chongqing Science and Technology Commission (No. cstc2019jcyj-msxmX0135), Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJQN202000442) and CQMU Chongqing Medical University (No. W0073) to W.W., and grants from Lingang Laboratory (No. LG202101-01-07), Science and Technology Commission of Shanghai Municipality (Nos.YDZX20213100001556 and 20XD1422900), Natural Science Foundation of Tianjin (No. 18JCJQJC48000) ,and Shanghai Municipal Development & Reform Commission Major Project (No. ZD2021CY001) to H.Y. This work was further supported by Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine, ShanghaiTech University.<EM><STRONG>??????? </STRONG></EM>H.Y. and W.W. conceived the project; W.C., H.Y., and W.W. designed the experiments; W.C., H.H., Z.L., and T.Z., cloned, expressed, purified, and crystallized proteins; Y.D. and H.W. col-lected the diffraction data; W.C., Y.D., H.W., and X.J. solved the crystal structure; H.H., W.C., Y.D., W.S., D.S., X.L., X.J., W.W., and H.Y. analyzed and discussed the data; H.C.N., X.J., W.W., and H.Y. wrote the manuscript."