"Coronaviruses, Lysosomes, and Secondary Bacterial Infections: Coronaviruses Outsmart the Host"

作者全名："Peng, Xiaohua; Cruz, Charles S. Dela S.; Sharma, Lokesh"

作者地址："[Peng, Xiaohua] Chongqing Med Univ, First Affiliated Hosp, Dept Rehabil Med, Chongqing, Peoples R China; [Cruz, Charles S. Dela S.; Sharma, Lokesh] Yale Sch Med, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT 06510 USA; [Cruz, Charles S. Dela S.] Vet Affairs Med Ctr, Dept Internal Med, West Haven, CT 06516 USA"

通信作者："Cruz, CSD (通讯作者)，Yale Sch Med, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT 06510 USA.; Cruz, CSD (通讯作者)，Vet Affairs Med Ctr, Dept Internal Med, West Haven, CT 06516 USA."

来源：DNA AND CELL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000932743400001

JCR分区：Q2

影响因子：2.6

年份：2023

卷号：42

期号：4

开始页：189

结束页：193

文献类型：Article

关键词：coronavirus; COVID-19; secondary bacterial infections; lysosomes

摘要："Lysosomes are key organelles that contribute to homeostatic functions such as autophagy-mediated recycling of cellular components and innate immune response through phagocytosis-mediated pathogen killing during infections. Viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has developed unique adaptation to not only avoid lysosome-mediated destruction but also actively utilize lysosomal machinery to both enter and exit cells. To survive the highly hostile lysosomal environment, coronaviruses deacidify the lysosomes, potentially by manipulating H+ ion exchange across the lysosomal lumen, ensuring coronavirus survival. At the same time, this deacidification not only impairs cellular homeostatic functions such as autophagy but also renders the host susceptible to secondary bacterial infections. Furthermore, lysosomal enzymes promote extensive cell death and tissue damage during secondary bacterial infections. Thus, targeting lysosomal pathways provide a great opportunity to limit both viral replication and subsequent negative impact on host immunity against secondary bacterial infections."

基金机构：Parker B. Francis Foundation award; Catalyst Award from the American Lung Association; Veterans affairs [VA BX004661]; Department of Defense grant

基金资助正文："Lokesh Sharma is supported by a Parker B. Francis Foundation award and a Catalyst Award from the American Lung Association. Charles Dela Cruz is supported by Veterans affairs grant VA BX004661, and Department of Defense grant."