Successful treatment with osimertinib for nonmucinous bronchioloalveolar carcinoma with massive bronchorrhea and respiratory failure: a case report and literature review

作者全名："Tong, Jin; Wang, Dao-Xin; Zhou, Zhi-Yu; Deng, Wang"

作者地址："[Tong, Jin; Wang, Dao-Xin; Zhou, Zhi-Yu; Deng, Wang] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Tong, Jin; Wang, Dao-Xin; Zhou, Zhi-Yu; Deng, Wang] Chongqing Med Res Ctr Resp & Crit Care Med, Chongqing, Peoples R China"

通信作者："Deng, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Chongqing, Peoples R China."

来源：TRANSLATIONAL CANCER RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000933911600001

JCR分区：Q4

影响因子：1.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Acute respiratory failure (ARF); bronchioloalveolar carcinoma (BAC); bronchorrhea; osimertinib; case report

摘要："Background: Correct diagnosis of bronchioloalveolar carcinoma (BAC) is often delayed due to the lack of familiarity with the condition among clinicians as its sporadic nature and its symptoms are similar to other respiratory issues. Among these, acute respiratory failure (ARF) caused by massive bronchorrhea is rarely associated with BAC. Here we first reported osimertinib in the treatment of BAC with bronchorrhea and ARF.Case Description: A 38-year-old woman presented with massive bronchorrhea and progressive dyspnea. A chest computed tomography (CT) scan showed consolidation with air bronchograms and multiple nodules in both lungs. The patient had no history of chronic pulmonary disease, diabetes mellitus, hypertension or smoke. The patient was initially diagnosed with pneumonia, but ARF developed despite the antibiotic therapy provided. Lung biopsy results revealed nonmucinous BAC. Osimertinib (80 mg daily) was prescribed and proved effective for the first time with an improved ARF and a decreased multiple nodules or consolidation in the lungs during the follow-up period.Conclusions: It is important for physicians to recognize the typical symptoms and radiological manifestations of BAC to avoid misdiagnosis or late diagnosis. This is especially important since early diagnosis allows for immediate epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy, which is a potentially beneficial treatment for patients with BAC."

基金机构：Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0008]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文：Acknowledgments Funding: This work was supported by the Chongqing Natural Science Foundation (No. cstc2020jcyj-msxmX0008) and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.