Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization

作者全名："Zhao, Shuang; He, Yi; Gao, Feiyu; Wei, Yue; Zhang, Jiawei; Chen, Mengxiao; Gao, Yunyun; Zhang, Yuan; Liu, Jun-Yan; Guo, Zufeng; Li, Zhenghua; Nie, Shenyou"

作者地址："[Zhao, Shuang; He, Yi; Gao, Feiyu; Wei, Yue; Zhang, Jiawei; Chen, Mengxiao; Gao, Yunyun; Zhang, Yuan; Liu, Jun-Yan; Guo, Zufeng; Nie, Shenyou] Chongqing Med Univ, Inst Life Sci, Ctr Novel Target & Therapeut Intervent, Chongqing 400016, Peoples R China; [Li, Zhenghua] Westlake Univ, Sch Sci, Hangzhou 310030, Zhejiang, Peoples R China"

通信作者："He, Y; Nie, SY (通讯作者)，Chongqing Med Univ, Inst Life Sci, Ctr Novel Target & Therapeut Intervent, Chongqing 400016, Peoples R China.; Li, ZH (通讯作者)，Westlake Univ, Sch Sci, Hangzhou 310030, Zhejiang, Peoples R China."

来源：CHEMICAL COMMUNICATIONS

ESI学科分类：CHEMISTRY

WOS号：WOS:000935847300001

JCR分区：Q2

影响因子：4.9

年份：2023

卷号：59

期号：21

开始页：3099

结束页：3102

文献类型：Article

关键词：　

摘要："Highly efficient synthesis of diverse 2,2-disubstituted 3-methyleneindoline derivatives through a one-pot base-promoted post-Ugi 5-exo-dig ""Conia-ene""-type cyclization has been disclosed. The mechanism study indicates that an intramolecular hydrogen bond may play a vital role in this process. The antiproliferative evaluation of cancer cell lines reveals that this protocol provides practical use in the green synthesis of bioactive compound libraries."

基金机构："Chongqing Medical University [W0045]; Fundamental Research Project of The Science and Technology Bureau, Yuzhong District, Chongqing [X91007]; High-Level Innovation Platform Project of Chongqing [2022-14]; Innovative Group of Natural Science Foundation of Chongqing [CXQT21016]; National Natural Science Foundation of China [22101235]"

基金资助正文："This research project was supported by the research foundation of Program for Youth Innovation in Future Medicine from Chongqing Medical University (W0045); Fundamental Research Project of The Science and Technology Bureau, Yuzhong District, Chongqing (X91007); the High-Level Innovation Platform Project of Chongqing (2022-14); and Innovative Group of Natural Science Foundation of Chongqing (CXQT21016). Z. L.appreciates the National Natural Science Foundation of China(grant no. 22101235) for financial support."