"The short-term effects of air pollution exposure on preterm births in Chongqing, China: 2015-2020"

作者全名："Ming, Xin; He, Ziyi; Li, Yannan; Hu, Yaqiong; Yang, Yunping; Chen, Hongyan; Chen, Qin; Yang, Huan; Zhou, Wenzheng"

作者地址："[Ming, Xin; He, Ziyi; Li, Yannan; Hu, Yaqiong; Yang, Yunping; Chen, Hongyan; Zhou, Wenzheng] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Women & Childrens Hosp, Longshan Rd 120, Chongqing 401147, Peoples R China; [Chen, Qin; Yang, Huan] Third Mil Med Univ, Army Med Univ, Inst Toxicol, Coll Prevent Med, Chongqing 400038, Peoples R China"

通信作者："Zhou, WZ (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Women & Childrens Hosp, Longshan Rd 120, Chongqing 401147, Peoples R China."

来源：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000936047000002

JCR分区：Q2

影响因子：5.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Preterm birth; Air pollution; Distributed lag non-linear models; Lag effect

摘要："Accumulating evidence suggested that the risk of preterm births (PTBs) following prenatal exposure to air pollution was inconclusive. The aim of this study is to investigate the relationship between air pollution exposure in the days before delivery and PTB and assess the threshold effect of short-term prenatal exposure to air pollution on PTB. This study collected data including meteorological factors, air pollutants, and information in Birth Certificate System from 9 districts during 2015-2020 in Chongqing, China. Generalized additive models (GAMs) with the distributed lag non-linear models were conducted to assess the acute impact of air pollutants on the daily counts of PTB, after controlling for potential confounding factors. We observed that PM2.5 was related to increased occurrence of PTB on lag 0-3 and lag 10-21 days, with the strongest on the first day (RR = 1.017, 95%CI: 1.000-1.034) and then decreasing. The thresholds of PM2.5 for lag 1-7 and 1-30 days were 100 mu g/m(3) and 50 mu g/m(3), respectively. The lag effect of PM10 on PTB was very similar to that of PM2.5. In addition, the lagged and cumulative exposure of SO2 and NO2 was also associated with the increased risk of PTB. The lag relative risk and cumulative relative risk of CO exposure were the strongest, with a maximum RR at lag 0 (RR = 1.044, 95%CI: 1.018, 1.069). Importantly, the exposure-response curve of CO showed that RR increased rapidly when the concentration exceeded 1000 mu g/m(3). This study indicated significant associations between air pollution and PTB. The relative risk decreases with day lag, while the cumulative effect increases. Thus, pregnant women should understand the risk of air pollution and try to avoid high concentration exposure."

基金机构：Chongqing Science and Technology Commission Project [cstc2020jcyj-msxmX0511]; foundation of Chongqing Health Center for Women and Children [2019YJMS04]

基金资助正文：This work was supported by the Chongqing Science and Technology Commission Project: The Association between Exposure to Ambient Air Pollution and Premature Birth and Low Birth Weight Outcomes in Chongqing Based on Birth Cohort [grant number: cstc2020jcyj-msxmX0511] and the foundation of Chongqing Health Center for Women and Children [grant number: 2019YJMS04].