Prognostic Value of the Cutoffs for HALP in Endometrial Cancer

作者全名："Wang, Jinyu; Jiang, Peng; Huang, Yuzhen; Tu, Yuan; Zhou, Qian; Li, Ning; Kong, Wei; Yuan, Rui"

作者地址："[Wang, Jinyu; Jiang, Peng; Huang, Yuzhen; Tu, Yuan; Zhou, Qian; Li, Ning; Kong, Wei; Yuan, Rui] Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China; [Yuan, Rui] Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Yuan, R (通讯作者)，Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000937162600004

JCR分区：Q4

影响因子：1.6

年份：2023

卷号：46

期号：3

开始页：107

结束页：113

文献类型：Article

关键词：endometrial cancer; HALP score; prognosis; critical value

摘要："Objectives:Using preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) scores, a cutoff value of HALP in endometrial cancer was identified, and the significance of HALP value in endometrial cancer prognosis was evaluated to guide the management of patients. Materials and Methods:This study included 626 patients with endometrial cancer who underwent surgery at the First Affiliated Hospital of Chongqing Medical University between June 2015 and June 2020. A Cox regression model was used to analyze the correlation between HALP endometrial cancer recurrence and death, and the receiver operating characteristic curve was used to determine the optimal cutoff value of HALP for predicting the lymph node metastasis (LNM), recurrence, and death of endometrial cancer. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Results:Univariate analysis revealed that HALP was associated with a lower risk of recurrence and death of endometrial cancer. Multivariate analysis indicated that HALP was an independent protective factor for predicting recurrence and death in endometrial cancer. The thresholds of HALP for predicting LNM, recurrence, and death in endometrial cancer patients are around 33.8. Kaplan-Meier survival curves showed that the recurrence-free and the overall survival rates were significantly lower in the low-HALP group than that in the high-HALP group (P<0.001). Conclusions:Preoperative HALP values in patients with endometrial cancer are important in predicting LNM, recurrence, and death of patients. HALP scores combined with traditional pathologic factors can better guide the prognostic management of patients."

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