Forster Resonance Energy Transfer Nanobullet for Photoacoustic Imaging and Amplified Photothermal-Photodynamic Therapy of Cancer

作者全名："Tan, Mixiao; Li, Xuemei; Zhang, Hua; Zheng, Min; Xiong, Jie; Cao, Yang; Cao, Guoliang; Wang, Zhigang; Ran, Haitao"

作者地址："[Tan, Mixiao; Li, Xuemei; Zhang, Hua; Zheng, Min; Xiong, Jie; Cao, Yang; Wang, Zhigang; Ran, Haitao] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Tan, Mixiao; Li, Xuemei; Zhang, Hua; Zheng, Min; Xiong, Jie; Cao, Yang; Wang, Zhigang; Ran, Haitao] Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Li, Xuemei] Dianjiang Peoples Hosp Chongqing, Chongqing 408300, Peoples R China; [Cao, Guoliang] CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China"

通信作者："Ran, HT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Ran, HT (通讯作者)，Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000937749000001

JCR分区：Q1

影响因子：10

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：forster resonance energy transfer; photoacoustic imaging; photodynamic therapy; photothermal therapy; tumor-homing cell-penetrating peptide

摘要："Synergistic photodynamic and photothermal therapy (PDT-PTT) has emerged as an appealing effective antitumor approach. However, clinical utilization of PDT-PTT is plagued by aggregation-caused photobleaching, sequential double irradiations, unsatisfying balance between single oxygen (O-1(2)) quantum yield and photothermal conversion efficiency. Here, an anchored tumor-homing cell-penetrating peptide (PEGA-pVEC) and PANI-ES/HMME loaded FRET nanobullet (AHP-P) are reported. Within nanobullet, HMME (donor) and PANI-ES (acceptor) spontaneously form a forster resonance energy transfer (FRET) pair. Upon 660 nm laser irradiation, HMME convert near-infrared fluorescence (NIRF) to PANI, thus produce FRET-amplified photoacoustic imaging guided PTT. In addition, AHP-P with pH-sensitivity can gradually release HMME within acidic tumor environment, boosts the O-1(2) regeneration alongside with highly efficient photothermal conversion for photoinduced cancer PTT-PDT. Furthermore, the AHP-P nanobullet can home in on the tumor site and penetrate into cytoplasm through PEGA-pVEC, inducing remarkable tumor regression with an approximate to 80% tumor volume reduction and decreased skin phototoxicity in vivo during FRET-amplified PTT-PDT."

基金机构："National Natural Science Foundation of China [82071926]; China Postdoctoral Science Foundation [2022MD713714]; Chongqing Postdoctoral Science Foundation [2021XM3111, CSTB2022NSCQ-BHX0620]"

基金资助正文："Acknowledgements M.T. and X.L. contributed equally to this work. The authors greatly acknowledge the financial support from the National Natural Science Foundation of China (82071926), China Postdoctoral Science Foundation funded projects (2022MD713714), and a Chongqing Postdoctoral Science Foundation funded project (2021XM3111 and CSTB2022NSCQ-BHX0620)."