Chronic Obstructive Pulmonary Disease Patients With High Peripheral Blood Eosinophil Counts Have Better Predicted Improvement in 6MWD After Rehabilitation A PRELIMINARY STUDY

作者全名："Shui, Li-Li; Cai, Ji-Jun; Zhong, Xiao-Qing; Li, You-Lun; He, Mao-Rui; Chen, Ya-Juan"

作者地址："[Shui, Li-Li; Cai, Ji-Jun; Zhong, Xiao-Qing; Li, You-Lun; He, Mao-Rui; Chen, Ya-Juan] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, China Mss, Chongqing, Peoples R China; [Chen, Ya-Juan] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China"

通信作者："Chen, YJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000938822200007

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：43

期号：2

开始页：122

结束页：128

文献类型：Article

关键词：COPD; eosinophil; pulmonary rehabilitation; 6MWD

摘要："Purpose:The objective of this investigation was to determine whether chronic obstructive pulmonary disease (COPD) patients with high blood eosinophil (EOS) counts had better improvement in 6-min walk test (6MWT) after pulmonary rehabilitation (PR). Methods:Fifty COPD patients were randomly assigned to either the rehabilitation group (RG) or the control group (CG). Patients in the RG (8 wk PR + routine medication) and the CG (routine medication) were followed for 32 wk. According to the blood EOS level, the RG was divided into an EOS >= 200 cells/mu L group and EOS < 200 cells/mu L group. The 6MWT distance, Borg Scale, and COPD Assessment Test (CAT) were evaluated before intervention and 8 wk and 32 wk later. Results:After the 8-wk intervention, 37 patients (19 RG/18 CG) completed the study. At 8-wk and 32-wk follow-up from baseline, a statistically significant difference was found between these two groups in the 6MWT, Borg Scale, and CAT. Compared with baseline, the 6MWT in the RG increased 49.1 +/- 40.2 m (95% CI, 29.7-68.5, P < .001) at 8 wk and 60.8 +/- 42.1 m (95% CI, 40.5-81.6, P < .001) at 32 wk. In addition, the improvement of 6MWT in the EOS >= 200 cells/mu L RG group was higher than that in the EOS < 200 cells/mu L group (40.1 +/- 17.6 m, 95% CI, 36.8-43.4; P = .036) at 32-wk follow-up from baseline. Conclusion:An 8-wk PR can improve the exercise capacity of COPD patients, and the benefits persistent for 24 wk. The improvement in the 6MWT was more significant in COPD patients with a high blood EOS count."

基金机构：　

基金资助正文：