Advanced Biomaterials for Promoting Endometrial Regeneration

作者全名："Yin, Zhe; Wang, Juan; Cui, Wenguo; Tong, Chao"

作者地址："[Yin, Zhe; Tong, Chao] Chongqing Med Univ, State Key Lab Maternal & Fetal Med Chongqing Munic, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Wang, Juan; Cui, Wenguo] Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed, Ruijin Hosp,Sch Med,Shanghai Key Lab Prevent & Tre, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China"

通信作者："Tong, C (通讯作者)，Chongqing Med Univ, State Key Lab Maternal & Fetal Med Chongqing Munic, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed, Ruijin Hosp,Sch Med,Shanghai Key Lab Prevent & Tre, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000939418400001

JCR分区：Q1

影响因子：10

年份：2023

卷号：　

期号：　

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文献类型：Review; Early Access

关键词：endometrial repair; biomedical materials; endometrium; stem cells

摘要："The endometrium, as the innermost structure of the uterine cavity, plays a direct role in the implantation of the fertilized egg, its conception, and the formation of normal menstruation. In recent years, with the increasing rate of uterus-related surgeries, the damaged endometrium often fails to repair itself to its original state, resulting in a high incidence of menstrual disorders and reduced fertility in women in their reproductive years. Therefore, it is essential to repair the damaged endometrium to reduce menstrual disorders, pregnancy difficulties, and other adverse events. Biomaterials have become an important medical tool for tissue repair due to their excellent biocompatibility, shape plasticity, and functional versatility. Functional biomedical materials play an important role in endometrial repair through rational design, which is expected to fundamentally address the current shortcomings of endometrial repair to maximize repair, maintain female fertility, and solve the problem of medically induced endometrial destruction. This review describes the potential and several aspects of the design, function, and application of different biomedical materials capable of repairing endometrium. In brief, this review provides a comprehensive summary and outlook of biomaterials for endometrial repair."

基金机构："National Key Research and Development Program of China [2020YFA0908200]; National Natural Science Foundation of China [51873107, 82071675, 81871189]"

基金资助正文："Acknowledgements This research was funded by the National Key Research and Development Program of China (2020YFA0908200) and National Natural Science Foundation of China (51873107, 82071675, 81871189)."