A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder

作者全名："Zeng, Jianguang; You, Lantao; Yang, Fan; Luo, Ya; Yu, Shuxian; Yan, Jiangnan; Liu, Mengqi; Yang, Xun"

作者地址："[Zeng, Jianguang; You, Lantao; Yu, Shuxian; Yan, Jiangnan] Chongqing Univ, Sch Econ & Business Adm, Chongqing, Peoples R China; [Yang, Fan] Sichuan Univ, West China Univ Hosp 2, Dept Ultrasonog, Chengdu, Peoples R China; [Yang, Fan] Sichuan Univ, Chengdu Chenghua Dist Maternal & Child Hlth Hosp, Chengdu, Peoples R China; [Luo, Ya] Sichuan Univ, West China Hosp, Dept Psychiat, State Key Lab Biotherapy, Chengdu, Peoples R China; [Liu, Mengqi] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Yang, Xun] Chongqing Univ, Sch Publ Affairs, Chongqing, Peoples R China; [Yang, Xun] Chongqing Univ, Sch Publ Affairs, 174 Shazhengjie, Chongqing 400044, Peoples R China"

通信作者："Yang, X (通讯作者)，Chongqing Univ, Sch Publ Affairs, 174 Shazhengjie, Chongqing 400044, Peoples R China."

来源：HUMAN BRAIN MAPPING

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000939822500001

JCR分区：Q1

影响因子：3.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：alcohol use disorder; functional magnetic resonance imaging; meta-analysis; monetary incentive delay task; neuroimaging; reward; striatum

摘要："The capacity to anticipate and detect rewarding outcomes is fundamental for the development of adaptive decision-making and goal-oriented behavior. Delineating the neural correlates of different stages of reward processing is imperative for understanding the neurobiological mechanism underlying alcohol use disorder (AUD). To examine the neural correlates of monetary anticipation and outcome in AUD patients, we performed two separate voxel-wise meta-analyses of functional neuroimaging studies, including 12 studies investigating reward anticipation and 7 studies investigating reward outcome using the monetary incentive delay task. During the anticipation stage, AUD patients displayed decreased activation in response to monetary cues in mesocortical-limbic circuits and sensory areas, including the ventral striatum (VS), insula, hippocampus, inferior occipital gyrus, supramarginal gyrus, lingual gyrus and fusiform gyrus. During the outcome stage, AUD patients exhibited reduced activation in the dorsal striatum, VS and insula, and increased activation in the orbital frontal cortex and medial temporal area. Our findings suggest that different activation patterns are associated with nondrug rewards during different reward processing stages, potentially reflecting a changed sensitivity to monetary reward in AUD."

基金机构："National Natural Science Foundation of China [31700964]; Science Research Project of School of Public Affairs in Chongqing University [2019GGXY04]; Venture & Innovation Support Program for Chongqing Overseas Returnees [cx2019154, cx2020119]; Social Science Foundation of Chongqing [2020YBGL80]"

基金资助正文："ACKNOWLEDGMENTS This study was supported by the National Natural Science Foundation of China (Grant No. 31700964), Science Research Project of School of Public Affairs in Chongqing University (Grant No. 2019GGXY04), Venture & Innovation Support Program for Chongqing Overseas Returnees (Grant Nos. cx2019154 and cx2020119) and Social Science Foundation of Chongqing (Grant No. 2020YBGL80)."