Psychiatric symptoms in a female with subacute combined degeneration of the spinal cord (SCD): a case report

作者全名："Zhang, Yinlin; Luo, Huirong; Wang, Xueqian; Qiu, Haitang; Ren, Hao; Zheng, Anhai; Luo, Qinghua"

作者地址："[Zhang, Yinlin; Luo, Huirong; Wang, Xueqian; Qiu, Haitang; Zheng, Anhai; Luo, Qinghua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Ren, Hao] Changshou Third Peoples Hosp, Dept Psychiat, Chongqing 401231, Peoples R China"

通信作者："Zheng, AH; Luo, QH (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000941968400002

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Subacute combined degeneration of the spinal cord (SCD); Vitamin B12; Psychiatric symptoms; Megaloblastic anemia; Case report

摘要："BackgroundSubacute combined degeneration of the spinal cord (SCD) is mainly caused by deficiency of Vitamin B12 and characterized by deep hypoesthesia, sensory ataxia and spasmodic paralysis of lower limbs. SCD often accompanies with megaloblastic anemia. Psychiatric symptoms could be the initial manifestations of SCD by lack of Vitamin B12, but are rarely considered secondary to physical discomfort and psychological factors in SCD. Additionally, treatment experience for psychiatric symptoms in SCD remains little reported.Case reportWe presented a case of a 37-year-old female who complained of being persecuted and controlled for one week and thus was admitted to the psychiatry department. Before that, she had went through persistent paresthesia and numbness of her lower extremities for two-month. Low Vitamin B12 level and hemoglobin concentration, neurologic symptoms and bone marrow smear results supported the clinical diagnosis of SCD and megaloblastic anemia. With supplementation of Vitamin B12 and blood transfusion and short-term prescription of antipsychotics and antidepressants, physical symptoms were improved and psychological symptoms disappeared within 2 weeks.ConclusionsPsychiatric symptoms of SCD could be generated from lack of Vitamin B12, anemia and neurologic symptoms, where short-term use of antipsychotics and antidepressants may be effective."

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