Ultrasonic-controlled ?explosive? hydrogels to precisely regulate spatiotemporal osteoimmune disturbance

作者全名："Han, Xiaoyu; Shen, Jieliang; Chen, Shuyu; Cai, Zhengwei; Zhu, Ying; Yi, Weiwei; Li, Kai; Cai, Weiye; Tao, Bailong; Cui, Wenguo; Bai, Dingqun"

作者地址："[Han, Xiaoyu; Chen, Shuyu; Zhu, Ying; Yi, Weiwei; Tao, Bailong; Bai, Dingqun] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China; [Han, Xiaoyu; Cai, Zhengwei; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med,Shanghai Key Lab Prevent &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China; [Shen, Jieliang; Li, Kai; Cai, Weiye] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China"

通信作者："Bai, DQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med,Shanghai Key Lab Prevent &, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：BIOMATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000943165300001

JCR分区：Q1

影响因子：12.8

年份：2023

卷号：295

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Ultrasound; Remote control; Explosiveness; Spatiotemporal osteoimmune disturbance; Bone regeneration

摘要："Spatiotemporal Immune disorder is a key factor leading to the failure of bone tissue healing. It is of vital importance to accurately suppress excessive peak immune response within 24-48 h of the injury and so regulate the spatiotemporal osteoimmune disturbance of bones. In this study, Ultrasound Controlled ""Explosive"" (UCE) hydrogels were prepared from gelatin-hyaluronic acid methacrylate hydrogels loaded with resveratrol nano-bubbles produced by double emulsification through a condensation reaction. Such materials innovatively enable ultrasound-controlled RES release for precise regulation of spatiotemporal osteoimmune disorders. Under an ultrasonic power level of 1.5 W/cm2, the rate of effectively released RES through the blast of UCE hydrogels reached 38.14 %. And compared with the control group, the in vivo inhibition of inflammation and osteogenesis effects of UCE hydrogels were more effective, respectively. As suggested by the results, the excessive local in-flammatory response was inhibited by the release of resveratrol, the temporospatial disorder of bone immune was precisely regulated, and as a result, the process of bone repair was accelerated. Altogether, this study confirms that the newly created UCE Hydrogels effectively promote bone repair by intervening peak inflam-mation during the early phase of fracture healing."

基金机构："National Key Research and Development Program of China [2020YFC2005900]; National Natural Science Foundation of China [82172533, 82002402, 32101104]; National Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0792]; Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing [CXQT21018]; State Key Laboratory of Ultrasound Engineering in Medicine and Engineering [2020KFA3019]; Shanghai Municipal Health Planning Commission [202140127]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0076]"

基金资助正文："This work was supported in part by the National Key Research and Development Program of China (2020YFC2005900), National Natural Science Foundation of China (82172533, 82002402 and 32101104) , The National Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0792), Chongqing Municipal Education Commission, Innovative Research Group of Universities in Chongqing (CXQT21018), State Key Laboratory of Ultrasound Engineering in Medicine and Engineering (2020KFA3019) , Shanghai Municipal Health Planning Commission (202140127), Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0076)."