Effects of multi-domain intervention on intrinsic capacity in older adults: A systematic review of randomized controlled trials (RCTs)

作者全名："Liao, Xiaoyan; Shen, Jun; Li, Miao"

作者地址："[Liao, Xiaoyan; Shen, Jun; Li, Miao] Chongqing Med Univ, Affiliated Hosp 1, Nursing Dept, 1 Youyi Rd, Chongqing 400014, Peoples R China"

通信作者："Shen, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Nursing Dept, 1 Youyi Rd, Chongqing 400014, Peoples R China."

来源：EXPERIMENTAL GERONTOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000943181100001

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：174

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Health aging; Intrinsic capacity; Multi-domain intervention; Elderly

摘要："Intrinsic capacity is central to the maintenance of function in older adults, and maintaining optimal intrinsic capacity is of great importance to promote healthy aging. The purpose of this systematic review and meta-analysis was to analyze the impact of multi-domain interventions on intrinsic capacity in older adults, inter-vention components, and potential interactions between components. A total of 6740 published articles were screened until August 2022, and the review included 25 randomized controlled trials that analyzed populations, interventions, control groups, and outcomes. The meta-analysis showed improvements in the primary outcome indicators in the intervention group compared to the control group. These included increased scores on the Mini-Mental State Examination as an indicator of cognitive function, decreased scores on the Geriatric Depression Scale (GDS-15) as an indicator of psychological ability and increased scores on the Short Physical Performance Battery (SPPB) as an indicator of physical performance, with only the SPPB indicator analyzed showing greater heterogeneity. Significant improvements were also seen in the secondary indicators Time-to-Walk Test (TUG), gait speed, Chair Stand Test (CST), grip strength values and BMI. There was insufficient data for the Mini Nutritional Assessment (MNA) as an indicator of vitality to conduct a meta-analysis. Studies were of moderate to high quality. The results of this review indicate that multi-domain interventions can maintain the level of intrinsic capacity in older adults and are equally effective in older adults with declining self-care abilities."

基金机构：National Social Science Fund of China [NSSFC: 22BRK010]

基金资助正文：Funding This work was supported by National Social Science Fund of China (NSSFC: 22BRK010) .