ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-KB Signaling Pathway

作者全名："Shao, Xin; Zhong, Liang; Chu, Xuan; Wan, Peng; Chen, Shuyu; Zhou, Ziwei; Zhang, Hongyan; Wang, Meng; Liu, Beizhong"

作者地址："[Shao, Xin; Chu, Xuan; Wan, Peng; Chen, Shuyu; Zhou, Ziwei; Zhang, Hongyan; Wang, Meng; Liu, Beizhong] Chongqing Med Univ, Cent Lab Yongchuan Hosp, Chongqing 402160, Peoples R China; [Zhong, Liang; Liu, Beizhong] Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R China"

通信作者："Liu, BZ (通讯作者)，Chongqing Med Univ, Cent Lab Yongchuan Hosp, Chongqing 402160, Peoples R China.; Liu, BZ (通讯作者)，Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000943290900005

JCR分区：Q1

影响因子：3.2

年份：2023

卷号：20

期号：4

开始页：520

结束页：529

文献类型：Article

关键词：Acute myeloid leukemia; COMMD7; ZNF460; NF-KB pathway; Proliferation

摘要："Acute myeloid leukemia (AML) is a malignancy of the hematological system, for which there remains an urgent need for new therapeutic and diagnostic targets. COMM domain containing 7 (COMMD7) is a recently-identified oncogene linked to poor prognosis in AML. COMMD7 regulates multiple signaling pathways, including nuclear factor-kappa B (NF -KB) signaling. Here, we report that COMMD7 is highly expressed in the AML cell lines KG1a and U937 and that its inhibition by shRNA reduced proliferation, promoted apoptosis and facilitated cell cycle arrest in the G2/M phase in relation to depression of the NF -KB pathway. Furthermore, zinc finger protein 460 (ZNF460) is overexpressed in AML and regulates COMMD7. We found that knockdown of ZNF460 downregulated the expression of COMMD7 while the NF -KB pathway was also inhibited. In addition, we noticed that knockdown of ZNF460 reduced proliferation and increased apoptosis rate of AML cells and that the cell cycle was blocked in the G2/M phase. In brief, our results revealed a critical effect of the ZNF460-COMMD7-NF-KB axis for the proliferation of AML cells. Therefore, COMMD7 may be a possible therapeutic target for AML."

基金机构：National Natural Science Foundation of China [81772280]; Key Technology Innovation Special of Key Industries of the Chongqing Science and Technology Bureau [csct2022ycjh-bgzxm0034]

基金资助正文：Funding This research was supported by grants from the National Natural Science Foundation of China (Grant Number 81772280) and Key Technology Innovation Special of Key Industries of the Chongqing Science and Technology Bureau (Grant Number csct2022ycjh-bgzxm0034) .