The advanced lung cancer inflammation index is a prognostic factor for gastrointestinal cancer patients undergoing surgery: a systematic review and meta-analysis

作者全名："Liu, Xu-Rui; Wang, Lian-Lian; Zhang, Bin; Liu, Xiao-Yu; Li, Zi-Wei; Kang, Bing; Yuan, Chao; Wei, Zheng-Qiang; Peng, Dong"

作者地址："[Liu, Xu-Rui; Wang, Lian-Lian; Zhang, Bin; Liu, Xiao-Yu; Li, Zi-Wei; Yuan, Chao; Wei, Zheng-Qiang; Peng, Dong] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing 400016, Peoples R China; [Kang, Bing] Chongqing Med Univ, Affiliated Hosp 1, Dept Clin Nutr, Chongqing 400016, Peoples R China"

通信作者："Peng, D (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF SURGICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000943688200001

JCR分区：Q1

影响因子：2.5

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Advanced lung cancer inflammation index; Gastrointestinal cancer; Colorectal cancer; Gastric cancer; Surgery; Prognosis

摘要："BackgroundThe advanced lung cancer inflammation index (ALI) is a comprehensive assessment indicator that can reflect inflammation and nutrition conditions. However, there are some controversies about whether ALI is an independent prognostic factor for gastrointestinal cancer patients undergoing surgical resection. Thus, we aimed to clarify its prognostic value and explore the potential mechanisms.MethodsFour databases including PubMed, Embase, the Cochrane Library, and CNKI were used for searching eligible studies from inception to June 28, 2022. All gastrointestinal cancers, including colorectal cancer (CRC), gastric cancer (GC), esophageal cancer (EC), liver cancer, cholangiocarcinoma, and pancreatic cancer were enrolled for analysis. We focused on prognosis most in the current meta-analysis. Survival indicators, including overall survival (OS), disease-free survival (DFS), and cancer-special survival (CSS) were compared between the high ALI group and the low ALI group. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was submitted as a supplementary document.ResultsWe finally included fourteen studies involving 5091 patients in this meta-analysis. After pooling the hazard ratios (HRs) and 95% confidence intervals (CIs), ALI was found to be an independent prognostic factor for both OS (HR = 2.09, I-2 = 92%, 95% CI = 1.53 to 2.85, P < 0.01), DFS (HR = 1.48, I-2 = 83%, 95% CI = 1.18 to 1.87, P < 0.01), and CSS (HR = 1.28, I-2 = 1%, 95% CI = 1.02 to 1.60, P = 0.03) in gastrointestinal cancer. After subgroup analysis, we found that ALI was still closely related to OS for CRC (HR = 2.26, I-2 = 93%, 95% CI = 1.53 to 3.32, P < 0.01) and GC (HR = 1.51, I-2 = 40%, 95% CI = 1.13 to 2.04, P = 0.006) patients. As for DFS, ALI also has a predictive value on the prognosis of CRC (HR = 1.54, I-2 = 85%, 95% CI = 1.14 to 2.07, P = 0.005) and GC (HR = 1.37, I-2 = 0%, 95% CI = 1.09 to 1.73, P = 0.007) patients.ConclusionALI affected gastrointestinal cancer patients in terms of OS, DFS, and CSS. Meanwhile, ALI was a prognostic factor both for CRC and GC patients after subgroup analysis. Patients with low ALI had poorer prognoses. We recommended that surgeons should perform aggressive interventions in patients with low ALI before the operation."

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