ACx-projecting cholinergic neurons in the NB influence the BLA ensembles to modulate the discrimination of auditory fear memory

作者全名："Yan, Yan; Song, Da; Jin, Yue; Deng, Yujun; Wang, Chunjian; Huang, Tao; Tang, Yuanhong; Yang, Yu; Zhang, Yun; Wang, Zhe; Dong, Zhifang; Wang, Yuetian; Zhao, Juan; Ni, Junjun; Li, Hui; Zhang, Jun; Lang, Yiran; Wu, Yili; Qing, Hong; Quan, Zhenzhen"

作者地址："[Yan, Yan; Song, Da; Jin, Yue; Deng, Yujun; Wang, Chunjian; Huang, Tao; Tang, Yuanhong; Wang, Yuetian; Zhao, Juan; Ni, Junjun; Li, Hui; Zhang, Jun; Qing, Hong; Quan, Zhenzhen] Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China; [Yang, Yu; Wu, Yili] Jining Med Univ, Shandong Collaborat Innovat Ctr Diag Treatment & B, Sch Mental Hlth, Shandong Key Lab Behav Med, Jining 272013, Peoples R China; [Zhang, Yun; Wang, Zhe] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China; [Zhang, Yun; Wang, Zhe] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100069, Peoples R China; [Dong, Zhifang] Chongqing Med Univ, Childrens Hosp, Natl Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Chongqin, Chongqing 400014, Peoples R China; [Lang, Yiran] Beijing Inst Technol, Beijing Adv Innovat Ctr Intelligent Robots & Syst, Beijing 100081, Peoples R China; [Wu, Yili] Wenzhou Med Univ, Inst Aging, Sch Mental Hlth, Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China"

通信作者："Qing, H; Quan, ZZ (通讯作者)，Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China.; Wu, YL (通讯作者)，Jining Med Univ, Shandong Collaborat Innovat Ctr Diag Treatment & B, Sch Mental Hlth, Shandong Key Lab Behav Med, Jining 272013, Peoples R China.; Wu, YL (通讯作者)，Wenzhou Med Univ, Inst Aging, Sch Mental Hlth, Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325000, Zhejiang, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000944129400001

JCR分区：Q1

影响因子：5.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Animals need discriminating auditory fear memory (DAFM) to survive, but the related neural circuits of DAFM remain largely unknown. Our study shows that DAFM depends on acetylcholine (ACh) signal in the auditory cortex (ACx), which is projected from the nucleus basalis (NB). At the encoding stage, optogenetic inhibition of cholinergic projections of NB-ACx obfuscates distinct tone-responsive neurons of ACx recognizing from fear-paired tone to fear-unpaired tone signals, while simultaneously regulating the neuronal activity and reactivation of basal lateral amygdala (BLA) engram cells at the retrieval stage. This NBACh-ACx-BLA neural circuit for the modulation of DAFM is especially dependent on the nicotinic ACh receptor (nAChR). A nAChR antagonist reduces DAFM and diminishes the increased magnitude of ACx tone-responsive neuronal activity during the encoding stage. Our data suggest a critical role of NBACh-ACx-BLA neural circuit in DAFM: manipulation of the NB cholinergic projection to the ACx via nAChR during the encoding stage affects the activation of ACx tone-responsive neuron clusters and the BLA engram cells during the retrieval stage, thus modulating the DAFM."

基金机构："National Natural Science Foundation of China [92049102, 82071395, 91749116, 81870832, 81870844, 2022ZD0206800]; Ministry of Science and Technology Key project [32070954]"

基金资助正文："This research was supported by the National Natural Science Foundation of China (Grant No. 92049102), the Ministry of Science and Technology Key project (Grant No.2022ZD0206800), and the National Natural Science Foundation of China (32070954, 82071395, 91749116, 81870832 & 81870844)."