"Non-coding RNA and arrhythmias: expression, function, and molecular mechanism"

作者全名："Zeng, Yuhong; Wu, Na; Zhang, Zhihui; Zhong, Li; Li, Guowei; Li, Yafei"

作者地址："[Zeng, Yuhong; Wu, Na; Li, Yafei] Army Med Univ, Mil Med Univ 3, Coll Prevent Med, Dept Epidemiol, 30 Gaotanyan St, Chongqing 400038, Peoples R China; [Zeng, Yuhong; Wu, Na; Li, Yafei] Army Med Univ, Mil Med Univ 3, Evidence based Med & Clin Epidemiol Ctr, Chongqing 400038, Peoples R China; [Zhang, Zhihui] Army Med Univ, Southwest Hosp, Ctr Circadian Metab & Cardiovasc Dis, Dept Cardiol, Chongqing 400038, Peoples R China; [Zhong, Li] Chongqing Med Univ, Cardiovasc Dis Ctr, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Li, Guowei] Guangdong Second Prov Gen Hosp, Ctr Clin Epidemiol & Methodol, 466 Xingang Middle Rd, Guangzhou 510317, Peoples R China"

通信作者："Li, YF (通讯作者)，Army Med Univ, Mil Med Univ 3, Coll Prevent Med, Dept Epidemiol, 30 Gaotanyan St, Chongqing 400038, Peoples R China.; Li, YF (通讯作者)，Army Med Univ, Mil Med Univ 3, Evidence based Med & Clin Epidemiol Ctr, Chongqing 400038, Peoples R China.; Li, GW (通讯作者)，Guangdong Second Prov Gen Hosp, Ctr Clin Epidemiol & Methodol, 466 Xingang Middle Rd, Guangzhou 510317, Peoples R China."

来源：EUROPACE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000945225100001

JCR分区：Q1

影响因子：7.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Non-coding RNAs; MicroRNAs; Long non-coding RNAs; Circular RNAs; Small non-coding RNAs; Arrhythmias

摘要："Arrhythmias are a class of cardiac dysfunction characterized by heart rate disturbances and heart rhythm abnormalities, which are associated with substantial morbidity and mortality. Due to the limited understanding of pathological mechanism, current antiarrhythmic drugs and invasive therapies on arrhythmias lack sufficient efficacy and are always accompanied by potential adverse effects. Non-coding RNAs (including microRNAs, long non-coding RNAs, circular RNAs, and other small non-coding RNAs) have been demonstrated to be involved in the occurrence and development of various diseases including arrhythmias, which opens a new prospect for exploring the mechanism of arrhythmias and developing new therapeutic targets. Therefore, in this review, we aimed to provide an overview of the expression of ncRNAs in various arrhythmias, their roles in the arrhythmia's development and pathophysiology, and the potential mechanism of ncRNAs in arrhythmias. As atrial fibrillation (AF) is the most common arrhythmia in clinical practice and current studies mainly focus on it, this review primarily discussed about AF. It was expected that this review may provide a basis for a better understanding of the mechanistic role of ncRNAs in arrhythmias and facilitate the development of mechanic-based therapeutic targets."

基金机构：National Natural Science Foundation of China [82073649]

基金资助正文：This study was supported by the National Natural Science Foundation of China (No. 82073649 to N.W.).