Advances in the role of SWI/SNF complexes in tumours

作者全名："Li, Ziwei; Zhao, Jiumei; Tang, Yu"

作者地址："[Li, Ziwei] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Women & Childrens Hosp, Chongqing, Peoples R China; [Zhao, Jiumei] Chongqing Nanchuan Dist Peoples Hosp, Chongqing, Peoples R China; [Tang, Yu] Kunming Med Univ, Yunnan Canc Hosp, Affiliated Hosp 3, Kunming, Peoples R China; [Tang, Yu] Zunyi Med Univ, Dept Genet, Guizhou, Peoples R China; [Tang, Yu] Kunming Med Univ, Affiliated Hosp 3, Kunming, Peoples R China; [Tang, Yu] Zunyi Med Univ, Guizhou, Peoples R China"

通信作者："Tang, Y (通讯作者)，Kunming Med Univ, Affiliated Hosp 3, Kunming, Peoples R China.; Tang, Y (通讯作者)，Zunyi Med Univ, Guizhou, Peoples R China."

来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000945345200001

JCR分区：Q2

影响因子：4.3

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Review; Early Access

关键词：diagnosis; molecular mechanism; SWI; SNF complex; treatment; tumour

摘要："Cancer development is a complex process involving both genetic and epigenetic changes. The SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, one of the most studied ATP-dependent complexes, plays an important role in coordinating chromatin structural stability, gene expression and post-translational modifications. The SWI/SNF complex can be classified into BAF, PBAF and GBAF according to their constituent subunits. Cancer genome sequencing studies have shown a high incidence of mutations in genes encoding subunits of the SWI/SNF chromatin remodelling complex, with abnormalities in one or more of these genes present in nearly 25% of all cancers, which indicating that stabilizing normal expression of genes encoding subunits in the SWI/SNF complex may prevent tumorigenesis. In this paper, we will review the relationship between the SWI/SNF complex and some clinical tumours and its mechanism of action. The aim is to provide a theoretical basis to guide the diagnosis and treatment of tumours caused by mutations or inactivation of one or more genes encoding subunits of the SWI/SNF complex in the clinical setting."

基金机构：Scientific Research project of Education Department of Yunnan Province [2023Y0787]

基金资助正文："Scientific Research project of Education Department of Yunnan Province, Grant/Award Number: 2023Y0787"