Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair

作者全名："Li, Jihong; Song, Jinlin; Meng, Di; Yi, Yin; Zhang, Ting; Shu, Yu; Wu, Xiaohong"

作者地址："[Li, Jihong; Song, Jinlin; Meng, Di; Yi, Yin; Zhang, Ting; Shu, Yu; Wu, Xiaohong] Chongqing Med Univ, Stomatol Hosp, 426 Songshibei Rd, Chongqing, Peoples R China; [Li, Jihong; Song, Jinlin; Meng, Di; Yi, Yin; Zhang, Ting; Shu, Yu; Wu, Xiaohong] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Li, Jihong; Song, Jinlin; Meng, Di; Yi, Yin; Zhang, Ting; Shu, Yu; Wu, Xiaohong] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Wu, XH (通讯作者)，Chongqing Med Univ, Stomatol Hosp, 426 Songshibei Rd, Chongqing, Peoples R China.; Wu, XH (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China.; Wu, XH (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：REGENERATIVE BIOMATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000946723800002

JCR分区：Q1

影响因子：5.6

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：electrospun microspheres; macrophage polarization; Ng-m-SAIB; osteoporotic bone defects

摘要："Repairing osteoporotic bone defects is still a major clinical challenge. Recent studies have revealed that immune response is also essential in osteogenesis. The intrinsic inflammatory response of the host, especially the M1/M2 polarization status and inflammatory secretory function of macrophages, can directly affect osteogenic differentiation. Therefore, in this study, an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate (Ng-m-SAIB) system was constructed to investigate its effect on the polarization of macrophage and osteoporotic bone defects. The results of both in vitro and in vivo experiments showed that Ng-m-SAIB had good biocompatibility and could promote the polarization of macrophage toward M2, thereby forming a favorable microenvironment for osteogenesis. The animal experiments also showed that Ng-m-SAIB could promote the osteogenesis of critical size defects in the skull of the osteoporotic model mouse (the senescence-accelerated mouse-strain P6). Together, these results collectively suggested that Ng-m-SAIB might be a promising biomaterial to treat osteoporotic bone defects with favorable osteo-immunomodulatory effects."

基金机构：National Natural Science Foundation of China [81970914]

基金资助正文：We are very grateful to the support from the National Natural Science Foundation of China (No. 81970914).