Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E

作者全名："Tao, Ran; Zhang, Qianyu; Duan, Jialing; Chen, Ran; Yao, Liyun; Zhang, Ruiteng; Dong, Gang; Chen, Huali"

作者地址："[Tao, Ran; Zhang, Qianyu; Duan, Jialing; Chen, Ran; Yao, Liyun; Zhang, Ruiteng; Dong, Gang; Chen, Huali] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China"

通信作者："Chen, HL (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China."

来源：JOURNAL OF MICROENCAPSULATION

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000946814100001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：3

开始页：157

结束页：170

文献类型：Article

关键词：Vitamin C; vitamin E; liposomes; transdermal permeability; antioxidant

摘要："AimsThe aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed.MethodsVitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using beta-carotene bleaching.ResultsVCVE-MVL with particle diameter of 848.55 +/- 0.29 nm and SPAN of 0.16 +/- 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)+/- 0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL.ConclusionsIn conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry."

基金机构：Chongqing Basic and Frontier Research Project [CSTC2018jcyjAX0126]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000407]; Chongqing College Student Innovation and Entrepreneurship Project [CXSY201856]; Program of Postgraduate Joint Training Base of Chongqing (Chongqing Medical University)

基金资助正文："The present study was supported by the Chongqing Basic and Frontier Research Project (grant no. CSTC2018jcyjAX0126), the Science and Technology Research Program of Chongqing Municipal Education Commission (grant no. KJQN202000407), the Chongqing College Student Innovation and Entrepreneurship Project (grant no. CXSY201856), and the Program of Postgraduate Joint Training Base of Chongqing (Chongqing Medical University & Yaopharma Co., Ltd joint training base for postgraduate in pharmacy)."