LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis

作者全名："Huang, Yongxiu; Peng, Meixi; Qin, Huanhuan; Li, Yan; Pei, Li; Liu, Xindong; Zhao, Xueya"

作者地址："[Huang, Yongxiu; Liu, Xindong] Chongqing Univ, Sch Med, 83 Shabei St, Chongqing 400044, Peoples R China; [Pei, Li] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Hematol, 30 Gaotan Yanzheng St, Chongqing 400038, Peoples R China; [Li, Yan; Zhao, Xueya] Chongqing Med Univ, Biol Sci Inst, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Qin, Huanhuan] Zunyi Med Univ, Zunyi 563000, Guizhou, Peoples R China; [Liu, Xindong] Army Med Univ, Southwest Hosp, Inst Pathol, Southwest Canc Ctr, Chongqing 400038, Peoples R China"

通信作者："Liu, XD (通讯作者)，Chongqing Univ, Sch Med, 83 Shabei St, Chongqing 400044, Peoples R China.; Pei, L (通讯作者)，Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Hematol, 30 Gaotan Yanzheng St, Chongqing 400038, Peoples R China.; Zhao, XY (通讯作者)，Chongqing Med Univ, Biol Sci Inst, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：CELLULAR SIGNALLING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000948708800001

JCR分区：Q2

影响因子：4.4

年份：2023

卷号：106

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Acute myeloid leukemia; LAPTM4B; Progression; RPS9; STAT3

摘要："Acute myeloid leukemia (AML) is a heterogeneous disorder with high morbidity and mortality under the existing treatment strategy. Here, we found that lysosome-associated protein transmembrane 4 beta (LAPTM4B) was frequently upregulated in AML, and high LAPTM4B was associated with poor outcome. Moreover, LAPTM4B promoted leukemia progression in vitro and in vivo. Mechanically, LAPTM4B interacted with RPS9, and positively regulated RPS9 protein stability, which enhanced leukemia cell progression via activating STAT3. Our findings indicate for the first time that LAPTM4B contributes to leukemia progression in a RPS9/STAT3-dependent manner, suggesting that LAPTM4B may serve as a promising target for treatment of AML."

基金机构：National Natural Science Foundation of China [31900588]; Natural Science Foundation of CQ CSTC [CSTB2022NSCQ-MSX1037]; Post- doctoral Science Foundation of China [2022M720607]

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (Grant No. 31900588) , the Natural Science Foundation of CQ CSTC (Grant No. CSTB2022NSCQ-MSX1037) , and Post- doctoral Science Foundation of China (Grant No. 2022M720607) ."