Presence and prospects of exosomal circRNAs in cancer (Review)

作者全名："Cui, Junjie; Wang, Jiaqi; Liu, Lianyu; Zou, Changwen; Zhao, Ying; Xue, Zhenyu; Sun, Xiaoxiong; Jiang, Tao; Song, Jun"

作者地址："[Cui, Junjie; Zhao, Ying; Xue, Zhenyu] Xuzhou Med Univ, Affiliated Hosp, Dept Radiat Oncol, Xuzhou 221002, Jiangsu, Peoples R China; [Wang, Jiaqi] Chongqing Med Univ, Affiliated Hosp 1, Dept Surg, Chongqing 400010, Peoples R China; [Liu, Lianyu; Zou, Changwen; Sun, Xiaoxiong; Jiang, Tao; Song, Jun] Xuzhou Med Univ, Affiliated Hosp, Dept Gen Surg, Xuzhou 221002, Jiangsu, Peoples R China; [Jiang, Tao; Song, Jun] Xuzhou Med Univ, Affiliated Hosp, Dept Gen Surg, 99 Huaihai West Rd, Xuzhou 221002, Jiangsu, Peoples R China"

通信作者："Jiang, T; Song, J (通讯作者)，Xuzhou Med Univ, Affiliated Hosp, Dept Gen Surg, 99 Huaihai West Rd, Xuzhou 221002, Jiangsu, Peoples R China."

来源：INTERNATIONAL JOURNAL OF ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000948915300001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：62

期号：4

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结束页：　

文献类型：Review

关键词：exosome; circRNA; exo-circRNAs; cancer

摘要："Exosomes are nanoscale extracellular vesicles secreted by parent cells and they are present in most bodily fluids, are able to carry active substances through intercellular transport and mediate communication between different cells, in particular those active in cancer. Circular RNAs (circRNAs) are novel noncoding RNAs expressed in most eukaryotic cells and are involved in various physiological and pathological processes, particularly in the occurrence and progression of cancer. Numerous studies have indicated a close relationship between circRNAs and exosomes. Exosomal circRNAs (exo-circRNAs) are a type of circRNA enriched in exosomes that may participate in the progression of cancer. Based on this, exo-circRNAs may have an important role in malignant behavioral manifestations of cancer and hold great promise in the diagnosis and treatment of cancer. The present review gives an introduction to the origin and functions of exosomes and circRNAs and elaborates on the mechanisms of exo-circRNAs in cancer progression. The biological functions of exo-circRNAs in tumorigenesis, development and drug resistance, as well as their role as predictive biomarkers, were discussed."

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