Research progress of glutathione peroxidase family (GPX) in redoxidation

作者全名："Pei, Jun; Pan, Xingyu; Wei, Guanghui; Hua, Yi"

作者地址："[Pei, Jun; Wei, Guanghui; Hua, Yi] Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China; [Pei, Jun; Wei, Guanghui; Hua, Yi] Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China; [Pan, Xingyu] Guizhou Prov Peoples Hosp, Dept Pediat Surg, Guiyang, Peoples R China"

通信作者："Hua, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China.; Hua, Y (通讯作者)，Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000949455400001

JCR分区：Q1

影响因子：4.4

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：glutathione peroxidase; redox balance; oxidative stress; inflammation; iron death

摘要："Maintaining the balance of a cell's redox function is key to determining cell fate. In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost all cellular processes. A total of eight members of the GPX family are currently found, namely GPX1-GPX8. They have long been used as antioxidant enzymes to play an important role in combating oxidative stress and maintaining redox balance. However, each member of the GPX family has a different mechanism of action and site of action in maintaining redox balance. GPX1-4 and GPX6 use selenocysteine as the active center to catalyze the reduction of H2O2 or organic hydroperoxides to water or corresponding alcohols, thereby reducing their toxicity and maintaining redox balance. In addition to reducing H2O2 and small molecule hydroperoxides, GPX4 is also capable of reducing complex lipid compounds. It is the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides. The active sites of GPX5 and GPX7-GPX8 do not contain selenium cysteine (Secys), but instead, have cysteine residues (Cys) as their active sites. GPX5 is mainly expressed in epididymal tissue and plays a role in protecting sperm from oxidative stress. Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca2+ in the endoplasmic reticulum. With an in-depth understanding of the role of the GPX family members in health and disease development, redox balance has become the functional core of GPX family, in order to further clarify the expression and regulatory mechanism of each member in the redox process, we reviewed GPX family members separately."

基金机构：Guizhou Provincial Science and Technology Projects [2018-1102]

基金资助正文：Funding This work was supported by Guizhou Provincial Science and Technology Projects (2018-1102).