Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation

作者全名："Wu, Yan; Li, Dan; Li, Mingzheng"

作者地址："[Li, Dan; Li, Mingzheng] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 400015, Peoples R China; [Wu, Yan] North Sichuan Med Coll, Dept Stomatol, Nanchong 637000, Peoples R China"

通信作者："Li, MZ (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 400015, Peoples R China."

来源：MEDICAL HYPOTHESES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000950054300001

JCR分区：Q3

影响因子：2.1

年份：2023

卷号：172

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Heterotopic ossification; Osteoclast; Osteoinduction

摘要："Current studies have identified that biomaterials in the form of sintered calcium phosphate (CaP) ceramics with specific physicochemical properties can induce bone formation in heterotopic sites without additional cells or growth factors, termed osteoinductive biomaterials, which display great potential in repairing large segmental bone defects. However, the underlying mechanism of osteoinduction remains elusive, preventing the optimal design of biomaterials with better osteogenic potential. Recently, accumulative evidence has illustrated that osteoclasts could recruit mesenchymal stem cells (MSCs) and enhance osteogenic differentiation of MSCs by secreting various cytokines, such as collagen triple helix repeat containing 1 (CTHRC1), sphingosine-1-phosphate (S1P), and complement factor 3a (C3a) during bone remodeling. Interestingly, a recent study found that osteoclastogenesis occurred prior to the bone formation during biomaterial-induced ectopic bone formation, and bone formation was blocked once osteoclastogenesis was inhibited with the anti-RANKL antibody at the early stage, which suggest that osteoclasts may play a critical role in the osteoinduction. However, whether osteoclasts could initiate biomaterial-induced ectopic bone formation remains unclear. Consequently, for the first time, we hypothesize that osteoclasts formed in non-osseous environments are perceived as a ""starting signal"" and osteoclastogenesis is the initiator of biomaterial-induced ectopic bone formation, which may provide useful instruction for osteoinductive materials modification and benefit the development of treatment strategies for heterotopic ossification (HO) in the future."

基金机构：China Postdoctoral Science Foundation [2021MD703929]; Postdoctoral Science Foundation of Chongqing Natural Science Foundation [cstc2021jcy-bsh0049]; Basic Research and Frontier Exploration Project of Chongqing [20210131]; CQMU Program for Youth Innovation in Future Medicine [W0095]

基金资助正文："This work was supported by the China Postdoctoral Science Foundation (No. 2021MD703929) , Postdoctoral Science Foundation of Chongqing Natural Science Foundation (No.cstc2021jcy-bsh0049) , Basic Research and Frontier Exploration Project of Chongqing (No. 20210131) , and CQMU Program for Youth Innovation in Future Medicine (No. W0095) . We thank Dr. Xiaoxiao Pang for his invaluable help in editing the manuscript."