Association of TBX21 gene polymorphisms and acute anterior uveitis risk in a Chinese population: A case-control study

作者全名:"Shan, Jiankang; Li, Lin; Du, Liping; Yang, Peizeng"

作者地址:"[Shan, Jiankang] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China; [Shan, Jiankang; Li, Lin; Du, Liping; Yang, Peizeng] Zhengzhou Univ, Henan Prov Eye Hosp, Dept Ophthalmol, Affiliated Hosp 1,Henan Int Joint Res Lab Ocular I, Zhengzhou, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Chongqing Eye Inst, Natl Clin Res Ctr Ocular Dis, Chongqing Key Lab Ophthalmol,Affiliated Hosp 1,Cho, Chongqing, Peoples R China"

通信作者:"Du, LP; Yang, PZ (通讯作者),Zhengzhou Univ, Henan Prov Eye Hosp, Dept Ophthalmol, Affiliated Hosp 1,Henan Int Joint Res Lab Ocular I, Zhengzhou, Peoples R China."

来源:EXPERIMENTAL EYE RESEARCH

ESI学科分类:CLINICAL MEDICINE

WOS号:WOS:000950230000001

JCR分区:Q1

影响因子:3

年份:2023

卷号:229

期号: 

开始页: 

结束页: 

文献类型:Article

关键词:Acute anterior uveitis; Polymorphism; TBX21; rs4794067; rs11657479

摘要:"Copy number variations (CNVs) in TBX21 gene have been reported to be significantly and positively correlated with acute anterior uveitis (AAU). Our study was performed to further determine whether single nucleotide polymorphisms (SNPs) in TBX21 gene confer susceptibility to AAU in a Chinese population. In our case-control study, 420 AAU patients and 918 healthy controls were included. SNP genotyping was conducted via the MassARRAYTM iPLEX Gold platform. Association and haplotype analyses were performed via SPSS 23.0 and SHEsis software. No significant association was observed between two candidate SNPs of TBX21 gene (rs4794067, rs11657479) and susceptibility to AAU (Pc > 0.05). In stratification analysis, the result also showed no significant difference between the HLA-B27 positive AAU patients and non-typed healthy controls. Addi-tionally, no association was detected between TBX21 haplotypes and AAU risk. In conclusion, the polymorphisms rs4794067 and rs11657479 in TBX21 gene did not confer disease susceptibility to AAU in a Chinese population."

基金机构:"National Natural Science Foundation of China [82171040, 81970792]; Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026]"

基金资助正文:"This work was supported by National Natural Science Foundation of China (82171040, 81970792) , and Medical Science and Technology Project of Health Commission of Henan Province (YXKC2020026) ."