Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction

作者全名："Deng, Xiang-liang; Yi, Han-wen; Xiao, Jin; Zhang, Xiao-fang; Zhao, Jin; Sun, Min; Wen, Xue-song; Liu, Zhi-qiang; Gao, Lei; Li, Zi-yang; Ge, Ping; Yu, Qi; Zhang, Dong-ying"

作者地址："[Deng, Xiang-liang; Yi, Han-wen; Xiao, Jin; Zhang, Xiao-fang; Zhao, Jin; Wen, Xue-song; Liu, Zhi-qiang; Gao, Lei; Li, Zi-yang; Yu, Qi; Zhang, Dong-ying] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Chongqing, Peoples R China; [Sun, Min; Ge, Ping] Chongqing Med Univ, Affiliated Hosp 1, Branch 1, Dept Cardiovasc Med, Chongqing, Peoples R China"

通信作者："Yu, Q; Zhang, DY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000950438100001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：serum uric acid; right ventricular dysfunction; heart failure with preserved ejection fraction; hyperuricemia; prognosis

摘要："BackgroundHyperuricemia and right ventricular dysfunction (RVD) are both widespread in heart failure with preserved ejection fraction (HFpEF) patients. RVD is associated with a poor prognosis in HFpEF. The correlation between serum uric acid (UA) levels and right ventricular function is unclear. The prognostic performance of UA in patients with HFpEF needs further validation. Methods and resultsA total of 210 patients with HFpEF were included in the study and divided into two groups according to UA level: the normal UA group (<= 7 mg/dl) and the high UA group (>7 mg/dl). The variables examined included clinical characteristics, echocardiography, and serum biochemical parameters. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular peak systolic velocity (TAPSV). Baseline characteristics were compared between the two groups, and the correlation between baseline UA and RVD was assessed using multifactorial binary logistic regression. Kaplan-Meier curves were used to describe all-cause mortality and heart failure readmission. Results showed that right ventricular function parameters were worse in the high UA group. After adjusting for UA, left ventricular posterior wall thickness (LVPWT), N-terminal B-type natriuretic peptide (NT-proBNP), atrial fibrillation (AF), and low-density lipoprotein cholesterol (LDL-C), UA (odds ratio = 2.028; p < 0.001) was independently associated with RVD, and UA >7 mg/dl (HR = 2.98; p < 0.001) was associated with heart failure readmission in patients with HFpEF. ConclusionElevated serum UA is closely associated with RVD and significantly associated with the heart failure readmission rate in patients with HFpEF."

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