Matthew effect photoimmunotheranostics enabled by proton-driven nanoconverter

作者全名："Wang, Jingjing; Zhang, Wei; Gu, Dachong; Chen, Chunmei; Tang, Wei; Ouyang, Yi; Liu, Xiaohong; Lu, Shi-Yu; Zhang, Xingcai; Han, Yulong; Hu, Jie; Xu, Ting; Cao, Yang; Ran, Haitao; Liu, Hui"

作者地址："[Wang, Jingjing; Gu, Dachong; Chen, Chunmei; Tang, Wei; Ouyang, Yi; Hu, Jie; Xu, Ting; Liu, Hui] Southwest Univ, Sch Mat & Energy, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China; [Zhang, Wei; Cao, Yang; Ran, Haitao] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Zhang, Wei; Liu, Xiaohong] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China; [Wang, Jingjing] Peking Univ, Sch Mat Sci & Engn, Beijing Innovat Ctr Engn Sci & Adv Technol BIC ESA, Beijing Key Lab Magnetoelect Mat & Devices BKL MMD, Beijing 100871, Peoples R China; [Lu, Shi-Yu] Chongqing Univ Sci & Technol, Coll Met & Mat Engn, Chongqing 401331, Peoples R China; [Zhang, Xingcai; Han, Yulong] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA; [Han, Yulong] MIT, Sch Engn, Cambridge, MA 02139 USA"

通信作者："Liu, H (通讯作者)，Southwest Univ, Sch Mat & Energy, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China.; Ran, HT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Liu, XH (通讯作者)，Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.; Zhang, XC (通讯作者)，Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:000950443500001

JCR分区：Q1

影响因子：13.3

年份：2023

卷号：462

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Matthew effect photoimmunotheranostics; Proton-driven enhanced nanoconverter; Reversible conversion; Tumor discrimination; ?OFF-ON-OFF? phototheranostics

摘要："The construction of novel photothermal agents (PTAs) with near-infrared (NIR) light-responsive capacity that can differentiate normal and abnormal tissues bidirectionally to minimize adverse effects of photothermal therapy (PTT) is of great importance yet a huge challenge. We are developing ""Matthew Effect Photo-immunotheranostics (MEP)"", demonstrated using an intelligent proton-driven enhanced nanoconverter (PEN) with self-refueling capacity by a facile polymerization method to form biocompatible photothermal agent pol-yaniline (PANI) with glucose oxidase (GOx) as the enhancer. PEN accumulates in the tumor region selectively after intravenous injection and GOx depletes glucose to re-establish the tumor microenvironment towards energy shortage and acidity aggravation, suppressing the expression of heat shock proteins to disturb the thermore-sistance mechanism of tumor cells and promoting the proton-driven conversion of PANI to activated state syn-ergistically. Strikingly, the PEN can differentiate normal and cancerous tissues bidirectionally with an ""OFF-ON-OFF"" mode to minimize adverse effects due to the enormous difference in glucose consumption between normal cells and tumor cells. PEN-mediated hyperthermia can induce immunogenic cell death. Under photoacoustic imaging and NIR-II light irradiation, PEN achieves tumor elimination with high specificity with synergistic mild hyperthermia/immune response by MEP. PEN-induced adaptive antitumor immunity is effective for eliminating distant tumors and suppressing tumor metastasis and recurrence."

基金机构："National Natural Science Founda-tion of China [51703184, 81630047]; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials"

基金资助正文："Acknowledgments This research was funded by the National Natural Science Founda-tion of China (51703184, 81630047) . This research was also supported by Chongqing Engineering Research Center for Micro-Nano Biomedical Materials."