Electroconvulsive therapy-induced neuroimaging alterations measured by cerebral blood flow in adolescents with major depressive disorder

作者全名："Yu, Ren-Qiang; Zhang, Zhu-Jun; Chen, Rong-sheng; Wang, Xing-Yu; Li, Xiao; Dai, Lin-Qi; Li, Zhen-Lin"

作者地址："[Yu, Ren-Qiang; Li, Zhen-Lin] Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China; [Yu, Ren-Qiang; Chen, Rong-sheng; Wang, Xing-Yu] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Zhang, Zhu-Jun] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu 610041, Sichuan, Peoples R China; [Li, Xiao; Dai, Lin-Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China"

通信作者："Li, ZL (通讯作者)，Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000950558200001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：327

期号：　

开始页：385

结束页：390

文献类型：Review

关键词：Major depressive disorder; Cerebral blood flow; Adolescent; Electroconvulsive therapy; Resting-state fMRI; Arterial spin labeling

摘要："Background: Electroconvulsive therapy (ECT) is a novel treatment strategy for adolescents with major depressive disorder (MDD). However, its related neurobiological changes associated with ECT remain undetermined. Objective: To elucidate the impact of ECT on the regional cerebral blood flow (CBF), and to identify alterations in the CBF associated with clinical outcomes in adolescents with MDD. Methods: Fifty-two treatment-naive adolescents who had experienced their first episode of MDD and 36 healthy controls (HCs) were recruited. To assess baseline parameters, all subjects were scanned with arterial spin labeling resting-state functional magnetic resonance imaging (ASL-fMRI) at the beginning of the study. Subsequently, 27 MDD adolescents were re-scanned after 2 weeks after ECT. CBF imaging was used for the prediction of specific clinical outcomes. Lastly, the associations between alterations seen on brain imaging alterations after ECT and ECT clinical efficacy (Delta HAMD scores) were determined.Results: Relative to HCs, adolescents with MDD exhibited reduced CBF in the left medial superior frontal gyrus (SFGmed) (cluster = 243, peak t = - 3.9373, and P < 0.001) and augmented CBF in the right percental gyrus (PerCG) (cluster = 321, peak t = 4.3332, and P < 0.001) at baseline. Following ECT, MDD adolescents exhibited reduced CBF in the right fusiform gyrus (FFG) (cluster = 309, peak t = - 4.346, and P < 0.001) and left hippocampus (HIP) (cluster = 290, peak t = - 4.706, and P < 0.001), and enhanced CBF in the left orbital part of the inferior frontal gyrus (ORBinf) (cluster = 214, peak t = 4.073, and P < 0.001). Correlation analysis suggested an inverse association between Delta HAMD scores and CBF values in the left ORBinf (R2 = 0.196, P = 0.021).Conclusions: It was found that ECT resulted in alterations in CBF in specific brain areas, highlighting the significance of ORBinf in ECT pathophysiology in MDD adolescents."

基金机构："National Key Research and Devel- opment of China [2021YFF0501504]; 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYGD18019]"

基金资助正文："Funding This work was supported by the National Key Research and Devel- opment of China [grant number 2021YFF0501504] ; and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [grant number ZYGD18019] ."