Association between short inter-pregnancy interval and placenta previa and placenta accreta spectrum with respect to maternal age at first cesarean delivery

作者全名："Liang, Yingyu; Zhang, Lizi; Huang, Lijun; Li, Yulian; Chen, Jingsi; Bi, Shilei; Huang, Minshan; Tan, Hu; Lai, Siying; Liang, Jingying; Gu, Shifeng; Jia, Jinping; Wen, Suiwen; Wang, Zhijian; Cao, Yinli; Wang, Shaoshuai; Xu, Xiaoyan; Feng, Ling; Zhao, Xianlan; Zhao, Yangyu; Zhu, Qiying; Qi, Hongbo; Zhang, Lanzhen; Li, Hongtian; Du, Lili; Chen, Dunjin"

作者地址："[Liang, Yingyu; Huang, Lijun; Li, Yulian; Chen, Jingsi; Bi, Shilei; Huang, Minshan; Tan, Hu; Lai, Siying; Liang, Jingying; Gu, Shifeng; Du, Lili; Chen, Dunjin] Guangzhou Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Key Lab Major Obstet Dis Guangdong Prov, Guangzhou, Peoples R China; [Zhang, Lizi; Wang, Zhijian] Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China; [Chen, Jingsi; Du, Lili; Chen, Dunjin] Guangdong Hong Kong Macao Greater Bay Area Higher, Guangzhou, Peoples R China; [Chen, Jingsi; Du, Lili; Chen, Dunjin] Guangdong Engn & Technol Res Ctr Maternal Fetal Me, Guangzhou, Peoples R China; [Chen, Jingsi; Du, Lili; Chen, Dunjin] Key Lab Reprod & Genet Guangdong Higher Educ Inst, 63 Duobao Rd, Guangzhou 510150, Guangdong, Peoples R China; [Jia, Jinping] Guangzhou Huadu Dist Maternal & Child Hlth Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China; [Wen, Suiwen] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China; [Cao, Yinli] Northwest Womens & Childrens Hosp, Dept Obstet & Gynecol, Xian, Peoples R China; [Wang, Shaoshuai; Xu, Xiaoyan; Feng, Ling] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China; [Zhao, Xianlan] Zhengzhou Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Zhengzhou, Peoples R China; [Zhao, Yangyu] Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China; [Zhu, Qiying] Xinjiang Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Urumqi, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Zhang, Lanzhen] Guangzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Guangzhou, Peoples R China; [Li, Hongtian] Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Natl Hlth Commiss Key Lab Reprod Hlth, Beijing, Peoples R China; [Chen, Dunjin] Guangzhou Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Guangzhou, Peoples R China"

通信作者："Du, LL; Chen, DJ (通讯作者)，Guangdong Hong Kong Macao Greater Bay Area Higher, Guangzhou, Peoples R China.; Du, LL; Chen, DJ (通讯作者)，Guangdong Engn & Technol Res Ctr Maternal Fetal Me, Guangzhou, Peoples R China.; Du, LL; Chen, DJ (通讯作者)，Key Lab Reprod & Genet Guangdong Higher Educ Inst, 63 Duobao Rd, Guangzhou 510150, Guangdong, Peoples R China.; Chen, DJ (通讯作者)，Guangzhou Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Guangzhou, Peoples R China."

来源：JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000952729400001

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：36

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Placenta previa; placenta accreta spectrum; inter-pregnancy interval; maternal age; cesarean delivery

摘要："Objective To explore the association between inter-pregnancy intervals and placenta previa and placenta accreta spectrum among women who had prior cesarean deliveries with respect to maternal age at first cesarean delivery. Methods This retrospective study included clinical data from 9981 singleton pregnant women with a history of cesarean delivery at 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017. The study population was divided into four groups (<2, 2-5, 5-10, >= 10 years of the interval) according to the inter-pregnancy interval. The rate of placenta previa and placenta accreta spectrum among the four groups was compared, and multivariate logistic regression was used to analyze the relationship between inter-pregnancy interval and placenta previa and placenta accreta spectrum with respect to maternal age at first cesarean delivery. Results Compared to women aged 30-34 years old at first cesarean delivery, the risk of placenta previa (aRR, 1.48; 95% CI, 1.16-1.88) and placenta accreta spectrum (aRR, 1.74; 95% CI, 1.28-2.35) were higher among women aged 18-24. Multivariate regression results showed that women at 18-24 with <2 years intervals exhibited a 5.05-fold increased risk for placenta previa compared with those with 2-5-year intervals (aRR, 5.05; 95% CI, 1.13-22.51). In addition, women aged 18-24 with less than 2 years intervals had an 8.44 times greater risk of developing PAS than women aged 30-34 with 2 to 5 years intervals (aRR, 8.44; 95% CI, 1.82-39.26). Conclusions The findings of this study suggested that short inter-pregnancy intervals were associated with increased risks for placenta previa, and placenta accreta spectrum for women under 25 years at first cesarean delivery, which may be partly attributed to obstetrical outcomes."

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