The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian randomization study

作者全名："Lin, Yi; Jiang, Bingcai; Cai, Yuanqing; Luo, Wangdu; Zheng, Changwei; Zhu, Xiaomin; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin"

作者地址："[Lin, Yi; Jiang, Bingcai; Luo, Wangdu; Zheng, Changwei; Zhu, Xiaomin; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin] Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing, Peoples R China; [Cai, Yuanqing] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Xian, Shaanxi, Peoples R China"

通信作者："Xie, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:000953310400001

JCR分区：Q2

影响因子：3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19; intraocular pressure; susceptibility; severity; criticality; Mendelian randomization

摘要："BackgroundCoronavirus disease 2019 (COVID-19) has brought great challenges to the global public health system and huge economic burdens to society, the causal effect of COVID-19 and intraocular pressure was blank. ObjectiveThis study aimed to explore the causal association between coronavirus disease (COVID-19) susceptibility, severity and criticality and intraocular pressure (IOP) by bidirectional Mendelian randomization (MR) analysis. Materials and methodsGenetic associations with COVID-19 susceptibility, severity and criticality were obtained from the COVID-19 Host Genetics Initiative. Genetic associations with IOP were obtained from GWAS summary data. The standard inverse variance weighted (IVW) method was used in the primary assessment of this causality. Other methods were also implemented in supplementary analyses. Finally, sensitivity analysis was performed to evaluate the reliability and stability of the results. ResultsThe results showed that COVID-19 susceptibility had null effect on IOP (beta = 0.131; Se = 0.211; P = 0.533) as assessed by the IVW method. Moreover, the results revealed that COVID-19 severity, specifically, hospitalization due to COVID-19, had a positive effect on IOP with nominal significance (beta = 0.228; Se = 0.116; P = 0.049). However, there were null effect of COVID-19 criticality on IOP (beta = 0.078; Se = 0.065; P = 0.227). Sensitivity analysis showed that all the results were reliable and stable. The reverse MR analysis revealed that there was null effect of IOP on COVID-19. ConclusionsWe demonstrated that hospitalization due to COVID-19 might increase IOP; therefore, greater attention should be given to monitoring IOP in inpatients with COVID-19."

基金机构："Natural Science Foundation of China [81470629, 81670860]; Chongqing Natural Research Foundation [cstc 2018jcyjAX0034]"

基金资助正文："The present study was supported by the Natural Science Foundation of China (Grant nos. 81470629 and 81670860; Chongqing, China) and Chongqing Natural Research Foundation (No. cstc 2018jcyjAX0034; Chongqing, China)."