Association of Behcet's disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis

作者全名："Chen, Tingqiao; Shao, Xinyi; Li, Hao; Chen, Yangmei; Liu, Lin; Zhong, Judan; Chen, Jin"

作者地址："[Chen, Tingqiao; Shao, Xinyi; Chen, Yangmei; Liu, Lin; Zhong, Judan; Chen, Jin] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Li, Hao] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Dermatol, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China"

通信作者："Chen, J (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000953790300001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Behcet's disease; Metabolic syndrome; Meta-analysis; Diabetes mellitus; Hypertension; Dyslipidemia

摘要："The present meta-analysis aimed to elucidate the association of Behcet's disease (BD) with the risk of metabolic syndrome (MetS) and its components. Observational cohort studies were searched from the Embase, Web of Science, Medline, and Cochrane Library databases. The primary outcome was the association of BD with the risk of MetS and its relevant components. Effect estimates with odds ratios (ORs) were pooled using either the random-effects or fixed-effects models, according to heterogeneity. Leave-one-out sensitivity analyses were used to determine the stability of the results. Twenty-three studies, comprising 42,834 patients with BD, were included. Overall, a significant association between BD and the risk of MetS was found (pooled OR 2.26; 95% confidence interval [CI] 1.61-3.17; P < 0.0001). Among the components of MetS, significant associations were found between BD and diabetes mellitus (OR 1.21; 95% CI 1.10-1.33; P < 0.0001), BD and hypertension (OR 1.39; 95% CI 1.13-1.70; P = 0.002), and BD and dyslipidemia (OR 1.21; 95% CI 1.01-1.45; P = 0.04). Our study indicated an association between BD and the risk of MetS and some of its components (diabetes mellitus, hypertension, and dyslipidemia). Physician should consider these associations so that specific treatments are available for patients with comorbidities. Moreover, patients with BD should regularly monitor their blood pressure, fasting plasma glucose, and blood lipid levels."

基金机构：National Natural Science Foundation of China [n82073462]

基金资助正文：This study was supported by the National Natural Science Foundation of China (Grant No.: n82073462).