Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy

作者全名："Wang, Chuanling; Zou, Qian; Pu, Yinshuang; Cai, Zhiyou; Tang, Yong"

作者地址："[Wang, Chuanling; Tang, Yong] Chongqing Med Univ, Sch Basic Med, Dept Histol & Embryol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Zou, Qian; Pu, Yinshuang; Cai, Zhiyou] Chongqing Key Lab Neurodegenerat Dis, 118 Xingguang Ave, Chongqing 401147, Peoples R China; [Zou, Qian; Pu, Yinshuang; Cai, Zhiyou] Chongqing Gen Hosp, Dept Neurol, 118 Xingguang Ave, Chongqing 401147, Peoples R China"

通信作者："Tang, Y (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Histol & Embryol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Cai, ZY (通讯作者)，Chongqing Key Lab Neurodegenerat Dis, 118 Xingguang Ave, Chongqing 401147, Peoples R China.; Cai, ZY (通讯作者)，Chongqing Gen Hosp, Dept Neurol, 118 Xingguang Ave, Chongqing 401147, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESI学科分类：CHEMISTRY

WOS号：WOS:000955397300001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：24

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：Alzheimer's disease; BBR; D-ribose; mitophagy; cognition

摘要："Mitochondrial dysfunction is considered an early event of Alzheimer disease (AD). D-ribose is a natural monosaccharide that exists in cells, especially in mitochondria, and can lead to cognitive dysfunction. However, the reason for this is unclear. Berberine (BBR) is an isoquinoline alkaloid that can target mitochondria and has great prospect in the treatment of AD. The methylation of PINK1 reinforces the burden of Alzheimer's pathology. This study explores the role of BBR and D-ribose in the mitophagy and cognitive function of AD related to DNA methylation. APP/PS1 mice and N2a cells were treated with D-ribose, BBR, and mitophagy inhibitor Mdivi-1 to observe their effects on mitochondrial morphology, mitophagy, neuron histology, AD pathology, animal behavior, and PINK1 methylation. The results showed that D-ribose induced mitochondrial dysfunction, mitophagy damage, and cognitive impairment. However, BBR inhibition of PINK1 promoter methylation can reverse the above effects caused by D-ribose, improve mitochondrial function, and restore mitophagy through the PINK1-Parkin pathway, thus reducing cognitive deficits and the burden of AD pathology. This experiment puts a new light on the mechanism of action of D-ribose in cognitive impairment and reveals new insights in the use of BBR for AD treatment."

基金机构：Chongqing Postdoctoral Science Foundation [CSTB2022NSCQ-BHX0634]; Chongqing Talents Project [cstc2021ycjh-bgzxm0198]

基金资助正文："This research was funded by Chongqing Postdoctoral Science Foundation, grant number CSTB2022NSCQ-BHX0634; Chongqing Talents Project, grant number cstc2021ycjh-bgzxm0198."