Hypocretin-1 suppresses malignant progression of glioblastoma cells through Notch1 signaling pathway

作者全名："Huan, Renzheng; Yue, Jianhe; Lan, Jinhai; Wang, Jia; Cheng, Yuan; Zhang, Jiqin; Tan, Ying"

作者地址："[Huan, Renzheng; Yue, Jianhe; Cheng, Yuan] Second Affiliated Hosp Chongqing Med Univ, Dept Neurosurg, Chongqing, Peoples R China; [Tan, Ying] Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China; [Zhang, Jiqin] Guizhou Prov Peoples Hosp, Dept Anesthesiol, Guiyang, Peoples R China; [Lan, Jinhai] Ziyun Peoples Hosp, Dept Surg 2, Anshun, Peoples R China; [Wang, Jia] Chongqing Emergency Med Ctr, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Cheng, Y (通讯作者)，Second Affiliated Hosp Chongqing Med Univ, Dept Neurosurg, Chongqing, Peoples R China.; Tan, Y (通讯作者)，Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China.; Zhang, JQ (通讯作者)，Guizhou Prov Peoples Hosp, Dept Anesthesiol, Guiyang, Peoples R China."

来源：BRAIN RESEARCH BULLETIN

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000955623600001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：196

期号：　

开始页：46

结束页：58

文献类型：Article

关键词：Glioblastoma; Hypocretin-1; Malignant progression; Notch signaling pathway

摘要："Hypocretin-1 is a multifunctional neuropeptide that has been identified as a potential antitumor agent for its role in inhibiting tumor growth, including in colon cancer, neuroendocrine tumor, and prostate cancer. However, the role and mechanism of hypocretin-1 in the occurrence and development of malignant glioma have not been well studied. Therefore, we investigated the effect of hypocretin-1 on glioblastoma proliferation, apoptosis, migration and invasion and its mechanism. We found that the hypocretin-1 receptor was expressed in both glioma cell lines and glioma tissues. Hypocretin-1 treatment can inhibit glioblastoma cell proliferation, migration and invasion, and induce cell apoptosis. Meanwhile, hypocretin-1 treatment significantly reduces tumor growth rate and tumor weight. In addition, mechanistic studies have found that hypocretin-1 exerts antitumor effects by inhibiting NOTCH signaling pathway. Overexpression of NICD significantly reversed the antitumor effect of hypocretin on glioblastoma. Taken together, these findings suggest that hypocretin-1 inhibits glioblastoma proliferation, migration and invasion and induces apoptosis in vitro and in vivo through NOTCH signaling pathway."

基金机构："National Natural Science Foundation of China [81960454, 81960344]; Guizhou Provincial Science and Technology Projects [[2020] 1Z066]; Guizhou Provincial People?s [cstc2020jcyj-msxmX0871, [2018] 06]; Guizhou Provincial People's Hospital National Science Foundation Hospital Doctor Foundation; National Science Foundation of Chongqing [GPPH-NSFC-D-2019-17]; [[2018] 03]; [GPPH-NSFC-2019-18]; [2019-09]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81960454, 81960344) , the Guizhou Provincial Science and Technology Projects ([2020] 1Z066) , Guizhou Provincial People's ( [2018] 06, [2018] 03) and Guizhou Provincial People's Hospital National Science Foundation Hospital Doctor Foundation (GPPH-NSFC-2019-18, 2019-09 and GPPH-NSFC-D-2019-17) and National Science Foundation of Chongqing (cstc2020jcyj-msxmX0871) ."