A Sleep-Specific Midbrain Target for Sevoflurane Anesthesia
作者全名："Yi, Tingting; Wang, Na; Huang, Jing; Wang, Yaling; Ren, Shuancheng; Hu, Yiwen; Xia, Jianxia; Liao, Yixiang; Li, Xin; Luo, Fenlan; Ouyang, Qin; Li, Yu; Zheng, Ziyi; Xiao, Qin; Ren, Rong; Yao, Zhongxiang; Tang, Xiangdong; Wang, Yanjiang; Chen, Xiaowei; He, Chao; Li, Hong; Hu, Zhian"
作者地址："[Yi, Tingting; Huang, Jing; Hu, Yiwen; Li, Yu; Li, Hong] Third Mil Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Chongqing 400037, Peoples R China; [Wang, Na; Wang, Yaling; Ren, Shuancheng; Xia, Jianxia; Liao, Yixiang; Li, Xin; Luo, Fenlan; Zheng, Ziyi; Xiao, Qin; Yao, Zhongxiang; He, Chao; Hu, Zhian] Third Mil Med Univ, Dept Physiol, Chongqing 400038, Peoples R China; [Wang, Na; Hu, Zhian] Chongqing Univ, Coll Bioengn, Chongqing 400044, Peoples R China; [Ouyang, Qin] Third Mil Med Univ, Sch Pharm, Chongqing 400038, Peoples R China; [Ren, Rong; Tang, Xiangdong] Sichuan Univ, West China Hosp, Sleep Med Ctr, Mental Hlth Ctr,Dept Resp & Crit Care Med, Chengdu 610041, Peoples R China; [Wang, Yanjiang] Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China; [Chen, Xiaowei] Third Mil Med Univ, Brain Res Ctr, Collaborat Innovat Ctr Brain Sci, Chongqing 400038, Peoples R China; [Yi, Tingting] Chongqing Med Univ, Yongchuan Hosp, Dept Anesthesiol, Chongqing 402160, Peoples R China; [Hu, Zhian] Chongqing Inst Brain & Intelligence, Guangyang Bay Lab, Chongqing 400064, Peoples R China"
通信作者："Li, H (通讯作者)，Third Mil Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Chongqing 400037, Peoples R China.; He, C; Hu, ZA (通讯作者)，Third Mil Med Univ, Dept Physiol, Chongqing 400038, Peoples R China."
来源：ADVANCED SCIENCE
ESI学科分类：PHYSICS
WOS号：WOS:000955717700001
JCR分区：Q1
影响因子：14.3
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：Edinger-Westphal nucleus; general anesthesia; growth hormone secretagogue receptor; sevoflurane; sleep
摘要："Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1(+))/cocaine- and amphetamine-regulated transcript (CART(+)) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane-activated UCN1(+)/CART(+) cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1(+)/CART(+) neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1(+)/CART(+) neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia."
基金机构："Fund for Innovative Research Groups of the National Natural Science Foundation of China [31921003]; National Major Project of China Science and Technology Innovation 2030 [2021ZD0203400, 2021ZD0203201]; National Natural Science Foundation of China [32022030, 31970945, 82171265]"
基金资助正文："The authors thank Z. Zhang, M. M. Luo, M. Xu, and P. Mourrain for critical comments on the manuscript, X. Luo, X. M. Gu, and J.C. Li for proofreading and polishing the manuscript. This work was supported by grants from the Fund for Innovative Research Groups of the National Natural Science Foundation of China (31921003 to Z.A.H.), the National Major Project of China Science and Technology Innovation 2030 for Brain Science and Brain-Inspired Technology (2021ZD0203400 to Z.A.H. and 2021ZD0203201 to C.H.), and the National Natural Science Foundation of China (32022030 and 31970945 to C.H., 82171265 to H.L.)."
