Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis

作者全名："Ke, Xia; Chen, Ziqi; Wang, Xiaoqiang; Kang, Houyong; Hong, Suling"

作者地址："[Ke, Xia; Chen, Ziqi; Wang, Xiaoqiang; Kang, Houyong; Hong, Suling] Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Chongqing, Peoples R China; [Kang, Houyong; Hong, Suling] Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, 1,Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Kang, HY; Hong, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, 1,Youyi Rd, Chongqing 400016, Peoples R China."

来源：AUTOIMMUNITY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000956232400001

JCR分区：Q3

影响因子：3.3

年份：2023

卷号：56

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Quercetin; allergic rhinitis; Th1/Th2; Treg/Th17; NF-kappa B pathway

摘要："Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. Here, we aimed to explore the effects of quercetin on type 1 helper T (Th1)/Th2 and regulatory T cells (Treg)/Th17 balance. We established an ovalbumin (OVA)-induced mouse model and orally administered 20, 35, and 50 mg/kg/day quercetin. The nasal symptoms of mice were observed. The immunoglobulin levels, Treg/Th17-related factors, and pro-inflammatory factors were examined by ELISA. The differentiated inflammation cells were visualized using the diff-quick staining assay. The nasal histopathology was evaluated using H&E, periodic acid Schiff (PAS), and Giemsa staining assay. The results showed that quercetin attenuated OVA-induced rubbing and sneezing. Quercetin reduced IgE, IgG1, histamine, and increased IgG2 in serum. The number of differentiated inflammation cells and goblet cells in tissues that elevated by OVA was reduced by quercetin. Moreover, OVA increased the Treg cell percentage, the levels of IL-17, TGF-beta, IL-6, TNF-alpha, and decreased Th17 cell percentage, IL-10 and FOXP3 levels, while quercetin abrogated their levels induced by OVA. Additionally, quercetin inactivated the NF-kappa B pathway. Taken together, quercetin attenuated AR symptoms by balancing the Th1/Th2, Treg/Th17 ratios, and inactivating the NF-kappa B pathway. The results suggested that quercetin may use for AR treatment."

基金机构："Chongqing Science and Technology Commission, Chongqing Natural Science Foundation General Project [cstc2019jcyj-msxmX0506]; Chongqing Health Commission, Chongqing Science and Health Joint Medical Research Project [MSXM20192002]"

基金资助正文："This work was supported by the Chongqing Science and Technology Commission, Chongqing Natural Science Foundation General Project under grant number cstc2019jcyj-msxmX0506; the Chongqing Health Commission, Chongqing Science and Health Joint Medical Research Project under grant number MSXM20192002."