Strategies involving low-molecular-weight heparin for the treatment and prevention of venous thromboembolism in patients with obesity: A systematic review and meta-analysis

作者全名："Liu, Junjie; Qiao, Xi; Wu, Mingdong; Wang, Haiyang; Luo, Hailong; Zhang, Haolong; Chen, Yikuan; Sun, Jianming; Tang, Bo"

作者地址："[Liu, Junjie; Wu, Mingdong; Wang, Haiyang; Luo, Hailong; Zhang, Haolong; Chen, Yikuan; Sun, Jianming; Tang, Bo] Chongqing Med Univ, Affiliated Hosp 2, Vasc Abdominal & Hernia Surg, Chongqing, Peoples R China; [Qiao, Xi] Chongqing Med Univ, Clin Med Coll 2, Dept Clin Med, Chongqing, Peoples R China"

通信作者："Tang, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Vasc Abdominal & Hernia Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000957054700001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：venous thromboembolism; obesity; anticoagulant; low-molecularweight heparin; treatment; prevention

摘要："Introduction: Recent studies have indicated that the dosage of LMWH in patients with specific weights may be controversial. Therefore, we conducted a metaanalysis to explore an appropriate dosage of LMWH for the prevention and treatment of venous thromboembolism (VTE) in patients with obesity. Materials and methods: We searched the PubMed, EMBASE, and Cochrane Library databases up to July 23, 2022. Study selection, bias analysis, and information extraction were performed by three independent reviewers. The occurrence or recurrence of VTE and bleeding events were the primary outcomes we assessed. Results: Eleven studies (a total of 6266 patients) were included in the prevention group, and 6 studies (a total of 3225 patients) were included in the treatment group. For VTE prophylaxis, compared with the standard-dosage group, the high-dosage group had a lower incidence of VTE (OR: 0.47, 95% CI: 0.27-0.82, P=0.007) and a similar incidence of bleeding events (OR: 0.86, 95% CI: 0.69-1.08, P=0.020). For VTE therapy, compared to the standard-dosage group, the reduced-dosage group had a similar incidence of VTE recurrence (OR: 0.86, 95% CI: 0.11-6.84, P=0.89) but a lower incidence of bleeding events (OR: 0.30, 95% CI: 0.10-0.89, P=0.03). Conclusion: In patients with obesity, increasing the dosage of LMWH is a more appropriate option for the prevention of VTE. Due to the limited evidence,"

基金机构：National Natural Science Foundation of China [81400348]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文：This work was supported by a Grant from the National Natural Science Foundation of China (81400348) and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.