Inhibition of Integrin α_vβ₃-FAK-MAPK signaling constrains the invasion of T-ALL cells

作者全名："Huang, Lan; Zhu, Yao; Kong, Qinglin; Guan, Xianmin; Lei, Xiaoying; Zhang, Luying; Yang, Hui; Yao, Xinyuan; Liang, Shaoyan; An, Xizhou; Yu, Jie"

作者地址："[Huang, Lan; Zhu, Yao; Guan, Xianmin; Lei, Xiaoying; Zhang, Luying; Yang, Hui; Yao, Xinyuan; Liang, Shaoyan; An, Xizhou; Yu, Jie] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Minist Educ,Chongqing Key Lab Pediat,Childrens Hos, Chongqing, Peoples R China; [Kong, Qinglin] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Hematol & Oncol, Chengdu, Peoples R China; [An, Xizhou; Yu, Jie] Chongqing Med Univ, Dept Hematol & Oncol, Childrens Hosp, 136 Zhongshanerlu, Chongqing 400014, Peoples R China"

通信作者："An, XZ; Yu, J (通讯作者)，Chongqing Med Univ, Dept Hematol & Oncol, Childrens Hosp, 136 Zhongshanerlu, Chongqing 400014, Peoples R China."

来源：CELL ADHESION & MIGRATION

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000957123200001

JCR分区：Q3

影响因子：3.3

年份：2023

卷号：17

期号：1

开始页：1

结束页：14

文献类型：Article

关键词：Cell invasion; central nervous system infiltration; FAK; integrin beta 3; T-ALL

摘要："The role of adhesion receptor integrin alpha v beta 3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin beta 3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous system leukemia(CNSL) incidence. Decreasing of cell invasion was observed in Jurkat and Molt4 treated with integrin alpha v beta 3 specific antibody and inhibitor as well as cells with ITGB3 interference. Further, phosphorylation of FAK, cRAF, MEK and ERK decreased in cells with integrin alpha v beta 3 inhibition or interference. Invasion decreased in T-ALL cells treated with FAK and ERK inhibitors. In conclusion, inhibition of integrin alpha v beta 3 signals significantly limits the cell invasion of T-ALL cells."

基金机构：National Outstanding Youth Science Fund Project of National Natural Science Foundation of China [81700158]; Natural Science Foundation Project of Chongqing Science and Technology Bureau [cstc2020jcyj-msxmX0295]; Joint Medical Research Project of Chongqing Municipal Health Commission; Chongqing Science and Technology Bureau [2021MSXM231]

基金资助正文：The work was supported by the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China [81700158]; The Natural Science Foundation Project of Chongqing Science and Technology Bureau [No. cstc2020jcyj-msxmX0295]; Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau [No. 2021MSXM231].