Eradicating the tumor "seeds": nanomedicines-based therapies against cancer stem cells

作者全名："Li, Lin; Ni, Rui; Zheng, Dan; Chen, Lin"

作者地址："[Li, Lin; Zheng, Dan; Chen, Lin] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pharm, Chongqing 401147, Peoples R China; [Ni, Rui] Army Med Univ, Daping Hosp, Dept Pharm, Chongqing 400042, Peoples R China"

通信作者："Chen, L (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pharm, Chongqing 401147, Peoples R China."

来源：DARU-JOURNAL OF PHARMACEUTICAL SCIENCES

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000957440900001

JCR分区：Q3

影响因子：2.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Nanomedicine; Cancer stem cells; Cancer therapy; Drug delivery system

摘要："Objectives Cancer stem cells (CSCs), a small subpopulation of cells with high tumorigenesis and strong intrinsic drug resistance, exhibit self-renewal and differentiation abilities. CSCs play a crucial role in tumor progression, drug resistance, recurrence and metastasis,and conventional therapy is not enough to eradicate them. Therefore, developing novel therapies targeting CSCs to increase drug sensitivity and preventing relapse is essential. The objective of this review is to present nanotherapies that target and eradicate the tumor ""seeds"".Evidence acquisitionEvidence was collected and sorted from the literature ranging from 2000 to 2022, using appropriate keywords and key phrases as search terms within scientific databases such as Web of Science, PubMed and Google Scholar.Results Nanoparticle drug delivery systems have been successfully applied to gain longer circulation time, more precise targeting capability and better stability during cancer treatment. Nanotechnology-based strategies that have been used to target CSCs, include (1) encapsulating small molecular drugs and genes by nanotechnology, (2) targeting CSC signaling pathways, (3) utilizing nanocarriers targeting for specific markers of CSCs, (4) improving photothermal/ photodynamic therapy (PTT/PDT), 5)targeting the metabolism of CSCs and 6) enhancing nanomedicine-aided immunotherapy.Conclusion This review summarizes the biological hallmarks and markers of CSCs, and the nanotechnology-based therapies to kill them. Nanoparticle drug delivery systems are appropriate means for delivering drugs to tumors through enhanced permeability and retention (EPR) effect. Furthermore, surface modification with special ligands or antibodies improves the recognition and uptake of tumor cells or CSCs. It is expected that this review can offer insights into features of CSCs and the exploration of targeting nanodrug delivery systems."

基金机构："National Nature Science Foundation of China [81803029]; Science and Technology Foundation of Yuzhong District, Chongqing [20210179]"

基金资助正文："AcknowledgementsThis work was supported by the National Nature Science Foundation of China (No.81803029) and the Science and Technology Foundation of Yuzhong District, Chongqing (No.20210179)."