Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis

作者全名："Wang, Xiaoqiang; Shen, Yang; Ke, Xia; Hong, Suling"

作者地址："[Wang, Xiaoqiang; Shen, Yang; Ke, Xia; Hong, Suling] Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Chongqing, Peoples R China; [Wang, Xiaoqiang] 1, Youyi Rd, Chongqing, Peoples R China"

通信作者："Wang, XQ (通讯作者)，1, Youyi Rd, Chongqing, Peoples R China."

来源：IRANIAN JOURNAL OF IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000957766200009

JCR分区：Q4

影响因子：1.1

年份：2023

卷号：20

期号：1

开始页：92

结束页：103

文献类型：Article

关键词：Allergic Rhinitis; Interleukin-17; Interleukin-38; Peripheral Blood Mononuclear Cells; Th17 Cells

摘要："Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)-38 is thought to be involved in inhibiting cytokine secretion in the Th17 pathway. Objective: To evaluate the regulatory function of IL-38 on abnormal Th17 responses in Chinese patients with AR.Methods: Forty-five participants, divided into an AR group (n=25) and a control group (n=20), were recruited for the study. In addition, the expression of IL-38 and Th17-related cytokines was measured as well as the Th17 cell count in participants. By implementing recombinant IL-38 (rIL-38), the intervention of human peripheral blood mononuclear cells (PBMCs) was performed. Then, flow cytometry, polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA) were used to detect theTh17 milieu. Results: The expression of IL-38 in the AR group notably reduced compared with that in the control, whereas Th17 cell frequency and the expression levels of its transcription factor (RORC) and cytokines (IL-17A and IL-23) increased. The differentiation and immune function of Th17 cells in PBMCs were inhibited by rIL-38. Conclusion: Th17 responses are inhibited by IL-38 in patients with AR. Therefore, the obtained findings indicate that IL-38 is a potential therapeutic target for Chinese patients with AR. Xiaoqiang Tel/Fax: Wang Anti-inflammatory of Allergic 2023; Accepted:"

基金机构：Chongqing Natural Science Foundation [cstc2019jcyj-msxmX0862]

基金资助正文："This work was supported by the Chongqing Natural Science Foundation [grant number: cstc2019jcyj-msxmX0862] . The funding agency had no role in the study design, the collection, analysis, and interpretation of data, the writing of the report, or the decision to submit the article for publication."