Gut microbiota and its metabolites in depression: from pathogenesis to treatment

作者全名："Liu, Lanxiang; Wang, Haiyang; Chen, Xueyi; Zhang, Yangdong; Zhang, Hanping; Xie, Peng"

作者地址："[Liu, Lanxiang; Xie, Peng] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing 402160, Peoples R China; [Liu, Lanxiang; Wang, Haiyang; Chen, Xueyi; Zhang, Yangdong; Zhang, Hanping; Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Liu, Lanxiang; Zhang, Yangdong; Zhang, Hanping; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Wang, Haiyang; Xie, Peng] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China; [Wang, Haiyang; Xie, Peng] Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing 401147, Peoples R China; [Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EBIOMEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000958632800001

JCR分区：Q1

影响因子：9.7

年份：2023

卷号：90

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Gut microbiota; Metabolites; Depression; Pathogenesis; Microbial -targeted therapeutics

摘要："Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that compositional and functional (e.g., metabolite) changes in gut microbiota, known as dysbiosis, are associated with the onset and progression of depression via regulating the gut-brain axis. However, the gut microbiota and their metabolites present a double-edged sword in depression. Dysbiosis is involved in the pathogenesis of depression while, at the same time, offering a novel therapeutic target. In this review, we describe the association between dysbiosis and depression, drug-microbiota interactions in antidepressant treatment, and the potential health benefits of microbial-targeted therapeutics in depression, including dietary interventions, fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and postbiotics. With the emergence of microbial research, we describe a new direction for future research and clinical treatment of depression."

基金机构："Natural Science Foundation Project of China [82201683, 81820108015]"

基金资助正文："Acknowledgements This work was supported by the Natural Science Foundation Project of China (No. 82201683 and No. 81820108015) , the China Postdoctoral"