Characterization and prognosis of autoimmune encephalitis in the neurological intensive care unit: a retrospective study

作者全名："Qin, Ningxiang; Wang, Jing; Wu, Xingguo; Wang, Wei; Wang, Xuefeng; Peng, Xi; Wang, Liang"

作者地址："[Qin, Ningxiang; Wang, Jing; Wu, Xingguo; Wang, Wei; Wang, Xuefeng; Wang, Liang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Peng, Xi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Wang, L (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Peng, X (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：NEUROLOGICAL SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000959147300001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Autoimmune encephalitis (AE); NICU; Seizures; Prognosis

摘要："ObjectivePatients diagnosed with autoimmune encephalitis (AE) require admission to the neurological intensive care unit (ICU) when they exhibit clinical manifestations such as status epilepticus, central hypoventilation, and severe involuntary movements. In order to determine the predictors of ICU admission and prognosis for patients with AE admitted to the neurological ICU, we analyzed the clinical characteristics of this patient population.MethodsThis retrospective study analyzed 123 patients admitted to the First Affiliated Hospital of Chongqing Medical University between 2012 and 2021 who were diagnosed with AE based on serum and/or cerebrospinal fluid (CSF) AE-related antibody positivity. We divided these patients into two groups: those who received ICU treatment and those who did not. We evaluated patient's prognosis using the modified Rankin scales (mRS).ResultsUnivariate analysis revealed that epileptic seizures, involuntary movements, central hypoventilation, symptoms of vegetative neurological disorders, increased neutrophil-to-lymphocyte ratio (NLR), abnormal electroencephalogram (EEG) findings, and different treatments were associated with ICU admission for patients with AE. Multivariate logistic regression analysis showed that hypoventilation and NLR were independent risk factors for ICU admission in AE patients. Univariate analysis showed that age and sex were related to prognosis in ICU-treated AE patients, and logistic regression analysis indicated that age was the only independent risk factor for prognosis in ICU-treated AE patients.ConclusionIncreased NLR, except for hypoventilation, is an indicator of ICU admission in AE patients. Although a large number of patients with AE require ICU admission, the overall prognosis is good, particularly in younger patients."

基金机构："Joint Medical Research Project of Chongqing Science & Technology and Health Commission [2020FYYX081]; High-Level Medical Reserved Personnel Training Project of Chongqing; Natural Science Foundation of Yuzhong Direct, Chongqing [20190129]"

基金资助正文："This study was supported by the Joint Medical Research Project of Chongqing Science & Technology and Health Commission (2020FYYX081), High-Level Medical Reserved Personnel Training Project of Chongqing, and Natural Science Foundation of Yuzhong Direct, Chongqing (20190129)."