"An All-in-One ""4A Hydrogel"": through First-Aid Hemostatic, Antibacterial, Antioxidant, and Angiogenic to Promoting Infected Wound Healing"

作者全名："Hu, Shanshan; Yang, Zixin; Zhai, Qiming; Li, Dize; Zhu, Xingyu; He, Qingqing; Li, Lingjie; Cannon, Richard D.; Wang, Huanan; Tang, Han; Ji, Ping; Chen, Tao"

作者地址："[Hu, Shanshan; Yang, Zixin; Zhai, Qiming; Li, Dize; Zhu, Xingyu; He, Qingqing; Li, Lingjie; Tang, Han; Ji, Ping; Chen, Tao] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Cannon, Richard D.] Univ Otago, Sir John Walsh Res Inst, Fac Dent, Dept Oral Sci, Dunedin 9054, New Zealand; [Wang, Huanan] Dalian Univ Technol, Sch Bioengn, Key State Lab Fine Chem, Dalian 116023, Peoples R China"

通信作者："Tang, H; Ji, P; Chen, T (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：SMALL

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000959183900001

JCR分区：Q1

影响因子：13

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：diabetic mellitus; hemostasis; hydrogels; mussels; wound healing

摘要："Currently used wound dressings are ineffective. Hence, there is a need to develop introduce a high-performance medicament with multiple functions including rapid hemostasis and excellent antibacterial activity to meet the growing worldwide demand for wound healing products. Here, inspired by the strong adhesion of mussels and the enzyme-mimicking activity of nanometallic biomaterials, the authors developed an injectable hydrogel to overcome multiple limitations of current wound dressings. The hydrogel is synthesized via esterification reaction between poly(vinyl alcohol) (PVA) and 3,4-dihydroxyphenylalanine (DOPA), followed by catechol-metal coordination between Cu2+ and the catechol groups of DOPA to form a PVA-DOPA-Cu (PDPC) hydrogel. The PDPC hydrogel possesses excellent tissue adhesive, antioxidative, photothermal, antibacterial, and hemostatic properties. The hydrogel rapidly and efficiently stopped bleeding under different traumatic conditions, including otherwise-lethal liver injury, high-pressure carotid artery rupture, and even fatal cardiac penetration injuries in animal models. Furthermore, it is demonstrated that the PDPC hydrogel affected high-performance wound repair and tissue regeneration by accelerating re-epithelialization, promoting collagen deposition, regulating inflammation, and contributing to vascularization. The results show that PDPC hydrogel is a promising candidate for rapid hemorrhage control and efficient wound healing in multiple clinical applications."

基金机构："National Natural Science Foundation of China [82101066, 81701031, 32071362]; China Postdoctoral Science Foundation [2020M683265, 2020M683266]; Chongqing Post-doctoral Science Special Foundation [2010010005393991]; Natural Science Foundation of Chongqing, China [cstc2021jcyj-bshX0140]"

基金资助正文："S.H. and Z.Y. contributed equally to this work. This work was supported by grants from the National Natural Science Foundation of China (82101066, 81701031, 32071362), the China Postdoctoral Science Foundation (2020M683265, 2020M683266), the Chongqing Post-doctoral Science Special Foundation (2010010005393991), and the Natural Science Foundation of Chongqing, China (cstc2021jcyj-bshX0140)."