A new polysaccharide from Hawk tea: Structural characterization and immunomodulatory activity associated with regulating gut microbiota

作者全名："Yu, Bao; Zhang, Dan; Wu, Yingqin; Tao, Wei; Luorong, Quji; Luo, Juan; Tan, Lihong; Chen, Huan; Cao, Weiguo"

作者地址："[Yu, Bao; Zhang, Dan; Wu, Yingqin; Tao, Wei; Luorong, Quji; Luo, Juan; Chen, Huan; Cao, Weiguo] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China; [Tan, Lihong] Chongqing Med & Pharmaceut Coll, Coll Pharm, Chongqing 401331, Peoples R China"

通信作者："Cao, WG (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China."

来源：FOOD CHEMISTRY

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000959457500001

JCR分区：Q1

影响因子：8.5

年份：2023

卷号：418

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Polysaccharide; Hawk tea; Structure; Immunomodulatory; Gut microbiota

摘要："In this study, a novel 28.6 kDa acidic polysaccharide (HTP-1), containing-* 4)-GalpA-(1-*,-*2)-Rhap-(1-* and-* 3,6)-Galp-(1-* residues as the backbone, analogous to pectin, was isolated from mature Hawk tea leaves. HTP-1 exhibited significant immunoregulatory activities on CTX-induced immunosuppressed mice in a dose-depend manner by alleviating jejunum injury and improving the levels of immune organ indexes, cytokines and im-munoglobulins. Moreover, HTP-1 supplementation boosted the content of SCFAs, altered the intestinal micro-biota composition, and raised the abundances of beneficial bacteria Muribaculaceae, Lactobacillaceae, Bacteroidaceae, Prevotellaceae and Ruminococcaceae, which showed a strong positive correlation with most im-mune indicators. The current findings suggested that the immunomodulatory action of HTP-1 might rely on the regulation of the gut microbiota, and these results may also serve as a foundation for the future exploitation of HTP-1 as functional foods."

基金机构："Key R & D Projects in Artificial Intelligence Pilot Zone, Chongqing Science and Technology Bureau [cstc2020jscx-dxwtBX0054]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0070]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-M202215102, KJQN202002801]"

基金资助正文："This work was supported by Key R & D Projects in Artificial Intelligence Pilot Zone, Chongqing Science and Technology Bureau (cstc2020jscx-dxwtBX0054) . Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0070) . The Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJZD-M202215102 and KJQN202002801) ."