Nanomedicines for high-intensity focused ultrasound cancer treatment and theranostics (Review)

作者全名："Zheng, Qinyun; Xia, Bingxin; Huang, Xianlong; Luo, Jie; Zhong, Shigen; Li, Xuelin"

作者地址："[Zheng, Qinyun; Xia, Bingxin; Huang, Xianlong; Zhong, Shigen; Li, Xuelin] Chongqing Gen Hosp, Dept Hlth Management Ctr, Chongqing 401147, Peoples R China; [Luo, Jie] Chongqing Med Univ, Coll Biomed Engn, Chongqing 401147, Peoples R China; [Zhong, Shigen; Li, Xuelin] Chongqing Gen Hosp, Dept Hlth Management Ctr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China"

通信作者："Zhong, SG; Li, XL (通讯作者)，Chongqing Gen Hosp, Dept Hlth Management Ctr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China."

来源：EXPERIMENTAL AND THERAPEUTIC MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000960173600001

JCR分区：Q3

影响因子：2.4

年份：2023

卷号：25

期号：4

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结束页：　

文献类型：Review

关键词：high-intensity focused ultrasound; nanomaterial; cancer treatment; multi-model imaging; theranostics

摘要："High-intensity focused ultrasound (HIFU) is a promising and representative non-invasive therapeutic method for treating cancer with a high degree of efficacy. This non-invasive method induces tumour cell necrosis by increasing the local temperature and mechanical pressure. However, the clinical application of HIFU is limited given its low penetration depth and the incidence of off-target side effects. With their promising structural adjustability and targeting ability, nanomedicines have been adopted to improve the ablative efficacy of HIFU in the treatment of cancer. By selectively changing the acoustic environment (tissue structure, density and blood supply) of tumour tissue, these nanomedicines may allow for lower HIFU doses and treatment duration, while additionally achieving a higher degree of efficacy. The use of nanomedicines may also enable cancer theranostics of HIFU, allowing for precise cancer therapeutics. The present review aimed to provide an overview of advances in nanomedicines for HIFU cancer treatment and theranostics, stating their current limitations and future perspectives."

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