Angiotensin converting enzyme (ACE) gene I/D polymorphism is significantly associated with insulin resistance and polycystic ovary syndrome: a meta-analysis

作者全名："Li, Jie; Lin, Zhong; Wang, Shujia; Shi, Qiuling"

作者地址："[Li, Jie; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Li, Jie; Lin, Zhong; Wang, Shujia] Reprod Hosp Guangxi Zhuang Autonomous Reg, Nanning, Peoples R China; [Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Shi, QL (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：GYNECOLOGIC AND OBSTETRIC INVESTIGATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000960663700001

JCR分区：Q2

影响因子：2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："Introduction: This study was performed to clarify the effects of angiotensin converting enzyme (ACE) I/D polymorphism on the risk of insulin resistance and polycystic ovary syndrome (PCOS).Methods: Six genotype models and the mean difference (MD)/standardized mean difference (SMD) were applied to evaluate the effects of ACE I/D polymorphism on insulin resistance and PCOS risk.Results: Thirteen studies with 3212 PCOS patients and 2314 controls were collected. In the pooled analysis and Caucasian subgroup, the ACE I/D polymorphism was significantly associated with PCOS risk, even after removing the non-Hardy-Weinberg equilibrium (HWE) studies. Moreover, the positive effect of ACE I/D polymorphism in PCOS was mainly presented in Caucasians (removing non-HWE, DD + DI vs II: OR=2.15, P=0.017; DD vs DI + II: OR=2.64, P=0.007; DD vs DI: OR=2.48, P=0.014; DD vs II: OR=3.31, P=0.005; D vs I: OR=2.02, P=0.005) compared to Asians. Interestingly, only in the Asians was the ACE I/D polymorphism significantly correlated to insulin levels (DI vs II: SMD=0.19, 95%CI= (0.03, 0.35), P=0.023) and HOMA-IR (DI vs II: MD=0.50, 95%CI= (0.05, 0.95), P=0.031).Conclusions: The D allele of the ACE I/D polymorphism promotes PCOS development. Moreover, the ACE I/D polymorphism was also associated with insulin-resistant PCOS, especially among Asians."

基金机构：National Natural Science Foundation of China [81901538]; Guangxi Zhuang Autonomous Region Health Commission [Z-A20220363]

基金资助正文：This study was funded by the National Natural Science Foundation of China (grant numbers 81901538) and Self-funded research projects by Guangxi Zhuang Autonomous Region Health Commission (grant numbers Z-A20220363).