"Non-invasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in extremely preterm infants with respiratory distress syndrome: study protocol for a multicentre randomised controlled, superiority trial"

作者全名："Li, Yang; Zhu, Xingwang; Shi, Yuan"

作者地址："[Li, Yang] Maternal & Child Hlth Hosp Yongchuan, Dept Neonatol, Chongqing, Peoples R China; [Zhu, Xingwang; Shi, Yuan] Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing, Peoples R China"

通信作者："Shi, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing, Peoples R China."

来源：BMJ OPEN

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000960988700090

JCR分区：Q1

影响因子：2.4

年份：2023

卷号：13

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：NEONATOLOGY; RESPIRATORY MEDICINE (see Thoracic Medicine); Paediatric intensive & critical care

摘要："Introduction Tracheal intubation and invasive mechanical ventilation (IMV) significantly decreased mortality of respiratory distress syndrome (RDS) in extremely preterm infants (28 weeks' gestational age) whereas bronchopulmonary dysplasia increased. Thus, consensus guidelines recommend the use of non-invasive ventilation (NIV), as the preferred first-line approach for these infants. This trial aims to compare the effect of nasal continuous positive airway pressure (NCPAP) and non-invasive high-frequency oscillatory ventilation (NHFOV) as the primary respiratory support in extremely preterm infants with RDS. Methods and analysis We designed a multicentre, randomised, controlled, superiority trial investigating the effect of NCPAP and NHFOV as the primary respiratory support in extremely preterm infants with RDS in neonatal intensive units in China. At least 340 extremely preterm infants with RDS will be randomised to NHFOV or NCPAP as a primary mode of NIV. The primary outcomes will be the respiratory support failure determined by the need for IMV within 72 hours from birth. Ethics and dissemination Our protocol has been approved by the Ethics Committee of Children's Hospital of Chongqing Medical University. We will present our findings at national conferences and peer-reviewed paediatrics journals."

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