Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

作者全名："Xiong, Yue; Chen, Jianhui; Li, Yingbo"

作者地址："[Xiong, Yue; Chen, Jianhui; Li, Yingbo] Chongqing Med Univ, Inst Neurosci, Cerebrovasc Dis Lab, Chongqing, Peoples R China"

通信作者："Li, YB (通讯作者)，Chongqing Med Univ, Inst Neurosci, Cerebrovasc Dis Lab, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000961391700001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：17

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：autism spectrum disorders; microglia; astrocytes; neuroinflammation; synaptic pruning; mitochondria; methylation

摘要："Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in childhood. The mechanisms underlying ASD are unclear. In recent years, the role of microglia and astrocytes in ASD has received increasing attention. Microglia prune the synapses or respond to injury by sequestrating the injury site and expressing inflammatory cytokines. Astrocytes maintain homeostasis in the brain microenvironment through the uptake of ions and neurotransmitters. However, the molecular link between ASD and microglia and, or astrocytes remains unknown. Previous research has shown the significant role of microglia and astrocytes in ASD, with reports of increased numbers of reactive microglia and astrocytes in postmortem tissues and animal models of ASD. Therefore, an enhanced understanding of the roles of microglia and astrocytes in ASD is essential for developing effective therapies. This review aimed to summarize the functions of microglia and astrocytes and their contributions to ASD."

基金机构：Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0065]

基金资助正文：Funding This study was supported by the Natural Science Foundation of Chongqing (No. cstc2021jcyj-msxmX0065).